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                      "factor": "prior_anthracycline",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "prior_left_chest_or_mediastinal_rt",
                      "points": 0,
                      "present": false,
                      "tier": "medium"
                    },
                    {
                      "factor": "current_or_significant_smoker",
                      "points": 0,
                      "present": false,
                      "tier": "medium"
                    },
                    {
                      "factor": "obesity",
                      "points": 0,
                      "present": false,
                      "tier": "medium"
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "hfa_icos_raf_mek",
                  "formula_expression": "HFA-ICOS RAF-MEK (Lyon 2020): very_high if heart_failure_or_cardiomyopathy; high if mi_or_cabg or stable_angina or severe_valvular_heart_disease or prior_anthracycline or medium_points>=5; medium if medium_points 2-4; low if medium_points 0-1; medium_points = M2 (lvef 50-54, elevated_troponin, elevated_bnp, hypertension, prior_left_chest_or_mediastinal_rt) + M1 (arrhythmia, age>=65, diabetes, ckd, current_or_significant_smoker, obesity); LVEF <50 is not a printed High row on this table; age>=65 Medium 1 only (no High age band); cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
                  "lvef_percent": 60,
                  "medium_points": 0,
                  "risk_level": "low"
                }
              ],
              "path": "/api/calc/hfa_icos_raf_mek"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "body": {
                  "additionalProperties": false,
                  "properties": {
                    "items": {
                      "items": {
                        "properties": {
                          "age_years": {
                            "description": "Age in whole years (18-100). Lyon 2020 RAF-MEK table: age ≥65 is Medium 1. There is no High age band on this table. magent does not read an identity document.",
                            "type": "integer"
                          },
                          "arrhythmia": {
                            "description": "Atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation as assigned by the caller (Lyon 2020 RAF-MEK table footnote). true is Medium 1. magent does not read an ECG.",
                            "type": "boolean"
                          },
                          "ckd": {
                            "description": "Chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute eGFR.",
                            "type": "boolean"
                          },
                          "current_or_significant_smoker": {
                            "description": "Current smoker or significant smoking history as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1.",
                            "type": "boolean"
                          },
                          "diabetes": {
                            "description": "Diabetes mellitus (glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not assay haemoglobin A1c.",
                            "type": "boolean"
                          },
                          "elevated_bnp": {
                            "description": "Elevated baseline BNP or NT-proBNP above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay natriuretic peptides.",
                            "type": "boolean"
                          },
                          "elevated_troponin": {
                            "description": "Elevated baseline troponin above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay troponin.",
                            "type": "boolean"
                          },
                          "heart_failure_or_cardiomyopathy": {
                            "description": "Heart failure or cardiomyopathy as assigned by the caller (Lyon 2020 RAF-MEK table). true is Very high. magent does not diagnose heart failure.",
                            "type": "boolean"
                          },
                          "hypertension": {
                            "description": "Hypertension (systolic >140 mm Hg or diastolic >90 mm Hg, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not measure blood pressure.",
                            "type": "boolean"
                          },
                          "lvef_percent": {
                            "description": "Baseline LVEF in whole percent (10-80) as assigned by the caller. 50-54 is Medium 2. ≥55 adds no points. This table has no printed LVEF <50 High row; LVEF <50 does not raise risk_level by itself. magent does not read an echocardiogram.",
                            "type": "integer"
                          },
                          "mi_or_cabg": {
                            "description": "Myocardial infarction or CABG as assigned by the caller (Lyon 2020 RAF-MEK table). true is High.",
                            "type": "boolean"
                          },
                          "obesity": {
                            "description": "Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute BMI.",
                            "type": "boolean"
                          },
                          "prior_anthracycline": {
                            "description": "Prior anthracycline exposure as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not read a chemotherapy record.",
                            "type": "boolean"
                          },
                          "prior_left_chest_or_mediastinal_rt": {
                            "description": "Prior radiotherapy to the left chest or mediastinum as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2.",
                            "type": "boolean"
                          },
                          "severe_valvular_heart_disease": {
                            "description": "Severe valvular heart disease as assigned by the caller (Lyon 2020 RAF-MEK table). true is High.",
                            "type": "boolean"
                          },
                          "stable_angina": {
                            "description": "Stable angina as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not diagnose angina.",
                            "type": "boolean"
                          }
                        },
                        "required": [
                          "age_years",
                          "lvef_percent",
                          "heart_failure_or_cardiomyopathy",
                          "mi_or_cabg",
                          "stable_angina",
                          "severe_valvular_heart_disease",
                          "prior_anthracycline",
                          "elevated_troponin",
                          "elevated_bnp",
                          "hypertension",
                          "prior_left_chest_or_mediastinal_rt",
                          "arrhythmia",
                          "diabetes",
                          "ckd",
                          "current_or_significant_smoker",
                          "obesity"
                        ],
                        "type": "object"
                      },
                      "maxItems": 25,
                      "minItems": 1,
                      "type": "array"
                    }
                  },
                  "required": [
                    "items"
                  ],
                  "type": "object"
                },
                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "type": "object"
                },
                "type": {
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
  }
}