{ "x402Version": 2, "id": 39232, "slug": "39232", "resource": "https://api.magentlab.com/api/calc/crash", "description": "Extermann 2012 CRASH chemotherapy toxicity score (not trauma CRASH): diastolic BP, IADL, LDH versus ULN, caller-assigned MAX2 Chemotox, ECOG, Mini-Mental Status, Mini-Nutritional Assessment. Hematologic 0–6, nonhematologic 0–8, combined 0–12 counting Chemotox once. Four-level low/medium_low/medium_high/high bands with derivation incidences. Not a chemotherapy order and not CARG-TT. magent does not look up regimens.", "type": "http", "serviceName": "magent", "resourceType": "Agent Service", "accepts": [ { "scheme": "exact", "network": "eip155:8453", "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2", "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913", "amount": "5000", "amountUsd": 0.005, "maxTimeoutSeconds": 600 } ], "outputSchema": { "properties": { "example": { "type": "object" }, "type": { "type": "string" } }, "required": [ "type" ], "type": "object" }, "extensions": { "bazaar": { "info": { "iconUrl": "https://api.magentlab.com/favicon.ico", "input": { "body": { "items": [ { "chemotox": 0.5, "diastolic_mm_hg": 80, "ecog": 1, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "mms": 28, "mna": 26 }, { "chemotox": 0.5, "diastolic_mm_hg": 80, "ecog": 1, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "mms": 28, "mna": 26 } ] }, "method": "POST", "type": "http" }, "output": { "example": { "count": 2, "items": [ { "chemotox": 0.5, "citation": { "authors": "Extermann M, Boler I, Reich RR, et al.", "doi": "10.1002/cncr.26646", "id": "extermann-2012", "pmid": "22072065", "source": "Cancer. 2012;118(13):3377-3386", "title": "Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score" }, "combined_incidence_percent": 79, "combined_risk": "high", "combined_score": 10, "components": [ { "factor": "diastolic_mm_hg", "points": 1, "present": true, "value": 80 }, { "factor": "iadl", "points": 1, "present": true, "value": 20 }, { "factor": "ldh", "points": 2, "present": true, "value": 500 }, { "factor": "chemotox", "points": 1, "present": true, "value": 0.5 }, { "factor": "ecog", "points": 1, "present": true, "value": 1 }, { "factor": "mms", "points": 2, "present": true, "value": 28 }, { "factor": "mna", "points": 2, "present": true, "value": 26 } ], "diastolic_mm_hg": 80, "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "ecog": 1, "formula": "crash", "formula_expression": "CRASH (Extermann 2012 Table 4) hematologic = diastolic_mm_hg (<=72 0, >72 1) + iadl (26-29 0, 10-25 1) + ldh (ldh_u_l > 0.74 * ldh_uln_u_l 2 else 0; empty 1-point column) + chemotox (0-0.44 0, 0.45-0.57 1, >0.57 2); max 6; nonhematologic = ecog (0 → 0, 1-2 → 1, 3-4 → 2) + mms (30 → 0, <30 → 2) + mna (28-30 → 0, <28 → 2) + chemotox (same); max 8; combined = hematologic + nonhematologic - chemotox (count Chemotox once; max 12 not 14); H 0-1 low 7%, 2-3 medium_low 23%, 4-5 medium_high 54%, 6 high 100%; NH 0-2 low 33%, 3-4 medium_low 46%, 5-6 medium_high 67%, 7-8 high 93%; combined 0-3 low 50%, 4-6 medium_low 58%, 7-9 medium_high 77%, 10-12 high 79%; not trauma CRASH; not CARG-TT; Chemotox is caller-assigned MAX2", "hematologic_incidence_percent": 54, "hematologic_risk": "medium_high", "hematologic_score": 5, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "max_combined_score": 12, "max_hematologic_score": 6, "max_nonhematologic_score": 8, "mms": 28, "mna": 26, "nonhematologic_incidence_percent": 67, "nonhematologic_risk": "medium_high", "nonhematologic_score": 6 }, { "chemotox": 0.5, "citation": { "authors": "Extermann M, Boler I, Reich RR, et al.", "doi": "10.1002/cncr.26646", "id": "extermann-2012", "pmid": "22072065", "source": "Cancer. 2012;118(13):3377-3386", "title": "Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score" }, "combined_incidence_percent": 79, "combined_risk": "high", "combined_score": 10, "components": [ { "factor": "diastolic_mm_hg", "points": 1, "present": true, "value": 80 }, { "factor": "iadl", "points": 1, "present": true, "value": 20 }, { "factor": "ldh", "points": 2, "present": true, "value": 500 }, { "factor": "chemotox", "points": 1, "present": true, "value": 0.5 }, { "factor": "ecog", "points": 1, "present": true, "value": 1 }, { "factor": "mms", "points": 2, "present": true, "value": 28 }, { "factor": "mna", "points": 2, "present": true, "value": 26 } ], "diastolic_mm_hg": 80, "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "ecog": 1, "formula": "crash", "formula_expression": "CRASH (Extermann 2012 Table 4) hematologic = diastolic_mm_hg (<=72 0, >72 1) + iadl (26-29 0, 10-25 1) + ldh (ldh_u_l > 0.74 * ldh_uln_u_l 2 else 0; empty 1-point column) + chemotox (0-0.44 0, 0.45-0.57 1, >0.57 2); max 6; nonhematologic = ecog (0 → 0, 1-2 → 1, 3-4 → 2) + mms (30 → 0, <30 → 2) + mna (28-30 → 0, <28 → 2) + chemotox (same); max 8; combined = hematologic + nonhematologic - chemotox (count Chemotox once; max 12 not 14); H 0-1 low 7%, 2-3 medium_low 23%, 4-5 medium_high 54%, 6 high 100%; NH 0-2 low 33%, 3-4 medium_low 46%, 5-6 medium_high 67%, 7-8 high 93%; combined 0-3 low 50%, 4-6 medium_low 58%, 7-9 medium_high 77%, 10-12 high 79%; not trauma CRASH; not CARG-TT; Chemotox is caller-assigned MAX2", "hematologic_incidence_percent": 54, "hematologic_risk": "medium_high", "hematologic_score": 5, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "max_combined_score": 12, "max_hematologic_score": 6, "max_nonhematologic_score": 8, "mms": 28, "mna": 26, "nonhematologic_incidence_percent": 67, "nonhematologic_risk": "medium_high", "nonhematologic_score": 6 } ], "path": "/api/calc/crash" }, "type": "json" } }, "schema": { "$schema": "https://json-schema.org/draft/2020-12/schema", "properties": { "input": { "additionalProperties": false, "properties": { "body": { "additionalProperties": false, "properties": { "items": { "items": { "properties": { "chemotox": { "description": "Caller-assigned MAX2 Chemotox from 0 to 1. 0-0.44 → 0, 0.45-0.57 → 1, >0.57 → 2. Counted once in the combined score. magent does not look up regimens.", "type": "number" }, "diastolic_mm_hg": { "description": "Diastolic blood pressure in mm Hg (20-160). Extermann 2012 Table 4: ≤72 → 0, >72 → 1 hematologic point. magent does not measure blood pressure.", "type": "number" }, "ecog": { "description": "ECOG performance status integer 0-4. Extermann 2012: 0 → 0, 1-2 → 1, 3-4 → 2 nonhematologic points. magent does not assign performance status.", "type": "integer" }, "iadl": { "description": "Instrumental activities of daily living integer 10-29 (Extermann 2012 CRASH IADL). 26-29 → 0, 10-25 → 1 hematologic point. magent does not interview the patient.", "type": "integer" }, "ldh_u_l": { "description": "Lactate dehydrogenase in U/L (1-20000). +2 hematologic points if ldh_u_l > 0.74 × ldh_uln_u_l, else 0 (empty 1-point column). magent does not assay LDH.", "type": "number" }, "ldh_uln_u_l": { "description": "Laboratory LDH upper limit of normal in U/L (50-2000). Used only as 0.74 × ULN for the LDH rule. No special-case ULN value. magent does not assay LDH.", "type": "number" }, "mms": { "description": "Mini-Mental Status integer 0-30. Extermann 2012: 30 → 0, <30 → 2 nonhematologic points. magent does not administer the Mini-Mental Status.", "type": "integer" }, "mna": { "description": "Mini-Nutritional Assessment integer 0-30. Extermann 2012: 28-30 → 0, <28 → 2 nonhematologic points. magent does not administer the Mini-Nutritional Assessment.", "type": "integer" } }, "required": [ "diastolic_mm_hg", "iadl", "ldh_u_l", "ldh_uln_u_l", "chemotox", "ecog", "mms", "mna" ], "type": "object" }, "maxItems": 25, "minItems": 1, "type": "array" } }, "required": [ "items" ], "type": "object" }, "headers": { "additionalProperties": { "type": "string" }, "type": "object" }, "method": { "const": "POST", "type": "string" }, "type": { "const": "http", "type": "string" } }, "required": [ "type", "method" ], "type": "object" }, "output": { "properties": { "example": { "type": "object" }, "type": { "type": "string" } }, "required": [ "type" ], "type": "object" } }, "required": [ "input" ], "type": "object" } } }, "tags": [ "crash", "chemotherapy", "toxicity", "geriatric", "oncology", "bazaar" ], "sourceHost": "api.magentlab.com", "lastUpdated": "2026-10-13T02:06:14.973Z", "quality": { "calls30d": 5, "uniquePayers30d": 2, "lastCalledAt": "2026-10-13T02:06:14.83Z" }, "metadata": { "serviceName": "magent", "extensions": { "bazaar": { "info": { "iconUrl": "https://api.magentlab.com/favicon.ico", "input": { "body": { "items": [ { "chemotox": 0.5, "diastolic_mm_hg": 80, "ecog": 1, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "mms": 28, "mna": 26 }, { "chemotox": 0.5, "diastolic_mm_hg": 80, "ecog": 1, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "mms": 28, "mna": 26 } ] }, "method": "POST", "type": "http" }, "output": { "example": { "count": 2, "items": [ { "chemotox": 0.5, "citation": { "authors": "Extermann M, Boler I, Reich RR, et al.", "doi": "10.1002/cncr.26646", "id": "extermann-2012", "pmid": "22072065", "source": "Cancer. 2012;118(13):3377-3386", "title": "Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score" }, "combined_incidence_percent": 79, "combined_risk": "high", "combined_score": 10, "components": [ { "factor": "diastolic_mm_hg", "points": 1, "present": true, "value": 80 }, { "factor": "iadl", "points": 1, "present": true, "value": 20 }, { "factor": "ldh", "points": 2, "present": true, "value": 500 }, { "factor": "chemotox", "points": 1, "present": true, "value": 0.5 }, { "factor": "ecog", "points": 1, "present": true, "value": 1 }, { "factor": "mms", "points": 2, "present": true, "value": 28 }, { "factor": "mna", "points": 2, "present": true, "value": 26 } ], "diastolic_mm_hg": 80, "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "ecog": 1, "formula": "crash", "formula_expression": "CRASH (Extermann 2012 Table 4) hematologic = diastolic_mm_hg (<=72 0, >72 1) + iadl (26-29 0, 10-25 1) + ldh (ldh_u_l > 0.74 * ldh_uln_u_l 2 else 0; empty 1-point column) + chemotox (0-0.44 0, 0.45-0.57 1, >0.57 2); max 6; nonhematologic = ecog (0 → 0, 1-2 → 1, 3-4 → 2) + mms (30 → 0, <30 → 2) + mna (28-30 → 0, <28 → 2) + chemotox (same); max 8; combined = hematologic + nonhematologic - chemotox (count Chemotox once; max 12 not 14); H 0-1 low 7%, 2-3 medium_low 23%, 4-5 medium_high 54%, 6 high 100%; NH 0-2 low 33%, 3-4 medium_low 46%, 5-6 medium_high 67%, 7-8 high 93%; combined 0-3 low 50%, 4-6 medium_low 58%, 7-9 medium_high 77%, 10-12 high 79%; not trauma CRASH; not CARG-TT; Chemotox is caller-assigned MAX2", "hematologic_incidence_percent": 54, "hematologic_risk": "medium_high", "hematologic_score": 5, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "max_combined_score": 12, "max_hematologic_score": 6, "max_nonhematologic_score": 8, "mms": 28, "mna": 26, "nonhematologic_incidence_percent": 67, "nonhematologic_risk": "medium_high", "nonhematologic_score": 6 }, { "chemotox": 0.5, "citation": { "authors": "Extermann M, Boler I, Reich RR, et al.", "doi": "10.1002/cncr.26646", "id": "extermann-2012", "pmid": "22072065", "source": "Cancer. 2012;118(13):3377-3386", "title": "Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score" }, "combined_incidence_percent": 79, "combined_risk": "high", "combined_score": 10, "components": [ { "factor": "diastolic_mm_hg", "points": 1, "present": true, "value": 80 }, { "factor": "iadl", "points": 1, "present": true, "value": 20 }, { "factor": "ldh", "points": 2, "present": true, "value": 500 }, { "factor": "chemotox", "points": 1, "present": true, "value": 0.5 }, { "factor": "ecog", "points": 1, "present": true, "value": 1 }, { "factor": "mms", "points": 2, "present": true, "value": 28 }, { "factor": "mna", "points": 2, "present": true, "value": 26 } ], "diastolic_mm_hg": 80, "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "ecog": 1, "formula": "crash", "formula_expression": "CRASH (Extermann 2012 Table 4) hematologic = diastolic_mm_hg (<=72 0, >72 1) + iadl (26-29 0, 10-25 1) + ldh (ldh_u_l > 0.74 * ldh_uln_u_l 2 else 0; empty 1-point column) + chemotox (0-0.44 0, 0.45-0.57 1, >0.57 2); max 6; nonhematologic = ecog (0 → 0, 1-2 → 1, 3-4 → 2) + mms (30 → 0, <30 → 2) + mna (28-30 → 0, <28 → 2) + chemotox (same); max 8; combined = hematologic + nonhematologic - chemotox (count Chemotox once; max 12 not 14); H 0-1 low 7%, 2-3 medium_low 23%, 4-5 medium_high 54%, 6 high 100%; NH 0-2 low 33%, 3-4 medium_low 46%, 5-6 medium_high 67%, 7-8 high 93%; combined 0-3 low 50%, 4-6 medium_low 58%, 7-9 medium_high 77%, 10-12 high 79%; not trauma CRASH; not CARG-TT; Chemotox is caller-assigned MAX2", "hematologic_incidence_percent": 54, "hematologic_risk": "medium_high", "hematologic_score": 5, "iadl": 20, "ldh_u_l": 500, "ldh_uln_u_l": 618, "max_combined_score": 12, "max_hematologic_score": 6, "max_nonhematologic_score": 8, "mms": 28, "mna": 26, "nonhematologic_incidence_percent": 67, "nonhematologic_risk": "medium_high", "nonhematologic_score": 6 } ], "path": "/api/calc/crash" }, "type": "json" } }, "schema": { "$schema": "https://json-schema.org/draft/2020-12/schema", "properties": { "input": { "additionalProperties": false, "properties": { "body": { "additionalProperties": false, "properties": { "items": { "items": { "properties": { "chemotox": { "description": "Caller-assigned MAX2 Chemotox from 0 to 1. 0-0.44 → 0, 0.45-0.57 → 1, >0.57 → 2. Counted once in the combined score. magent does not look up regimens.", "type": "number" }, "diastolic_mm_hg": { "description": "Diastolic blood pressure in mm Hg (20-160). Extermann 2012 Table 4: ≤72 → 0, >72 → 1 hematologic point. magent does not measure blood pressure.", "type": "number" }, "ecog": { "description": "ECOG performance status integer 0-4. Extermann 2012: 0 → 0, 1-2 → 1, 3-4 → 2 nonhematologic points. magent does not assign performance status.", "type": "integer" }, "iadl": { "description": "Instrumental activities of daily living integer 10-29 (Extermann 2012 CRASH IADL). 26-29 → 0, 10-25 → 1 hematologic point. magent does not interview the patient.", "type": "integer" }, "ldh_u_l": { "description": "Lactate dehydrogenase in U/L (1-20000). +2 hematologic points if ldh_u_l > 0.74 × ldh_uln_u_l, else 0 (empty 1-point column). magent does not assay LDH.", "type": "number" }, "ldh_uln_u_l": { "description": "Laboratory LDH upper limit of normal in U/L (50-2000). Used only as 0.74 × ULN for the LDH rule. No special-case ULN value. magent does not assay LDH.", "type": "number" }, "mms": { "description": "Mini-Mental Status integer 0-30. Extermann 2012: 30 → 0, <30 → 2 nonhematologic points. magent does not administer the Mini-Mental Status.", "type": "integer" }, "mna": { "description": "Mini-Nutritional Assessment integer 0-30. Extermann 2012: 28-30 → 0, <28 → 2 nonhematologic points. magent does not administer the Mini-Nutritional Assessment.", "type": "integer" } }, "required": [ "diastolic_mm_hg", "iadl", "ldh_u_l", "ldh_uln_u_l", "chemotox", "ecog", "mms", "mna" ], "type": "object" }, "maxItems": 25, "minItems": 1, "type": "array" } }, "required": [ "items" ], "type": "object" }, "headers": { "additionalProperties": { "type": "string" }, "type": "object" }, "method": { "const": "POST", "type": "string" }, "type": { "const": "http", "type": "string" } }, "required": [ "type", "method" ], "type": "object" }, "output": { "properties": { "example": { "type": "object" }, "type": { "type": "string" } }, "required": [ "type" ], "type": "object" } }, "required": [ "input" ], "type": "object" } } } }, "liveness": { "reliability": null }, "verified": false, "featured": false, "provider": { "host": "api.magentlab.com", "manifest_name": "api.magentlab.com", "source": "cdp-mirror", "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources", "submitted_at": "2026-10-14T01:15:01.050Z" }, "exampleResponse": { "example": {}, "type": "string" } }