{
  "x402Version": 2,
  "id": 39390,
  "slug": "39390",
  "resource": "https://api.magentlab.com/api/calc/iota",
  "description": "Timmerman 2008 simple ultrasound rules. Caller assigns five M-rules (irregular solid tumor; ascites; ≥4 papillary structures; irregular multilocular-solid ≥100 mm; very high color Doppler) and five B-rules (unilocular cyst; solid component <7 mm; acoustic shadows; smooth multilocular <100 mm; no Doppler flow). Malignant if any M and no B; benign if any B and no M; otherwise inconclusive. magent does not read ultrasound. Not an ovarian-cancer diagnosis. Not RMI. Not Swede. Not SRRisk.",
  "type": "http",
  "serviceName": "magent",
  "resourceType": "Agent Service",
  "accepts": [
    {
      "scheme": "exact",
      "network": "eip155:8453",
      "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2",
      "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
      "amount": "5000",
      "amountUsd": 0.005,
      "maxTimeoutSeconds": 600
    }
  ],
  "outputSchema": {
    "properties": {
      "example": {
        "type": "object"
      },
      "type": {
        "type": "string"
      }
    },
    "required": [
      "type"
    ],
    "type": "object"
  },
  "extensions": {
    "bazaar": {
      "info": {
        "iconUrl": "https://api.magentlab.com/favicon.ico",
        "input": {
          "body": {
            "items": [
              {
                "acoustic_shadows": false,
                "ascites": true,
                "at_least_four_papillary_structures": false,
                "irregular_multilocular_solid_ge_100mm": false,
                "irregular_solid_tumor": false,
                "no_detectable_blood_flow": false,
                "smooth_multilocular_lt_100mm": false,
                "solid_component_lt_7mm": false,
                "unilocular_cyst": false,
                "very_high_color_doppler": false
              },
              {
                "acoustic_shadows": false,
                "ascites": true,
                "at_least_four_papillary_structures": false,
                "irregular_multilocular_solid_ge_100mm": false,
                "irregular_solid_tumor": false,
                "no_detectable_blood_flow": false,
                "smooth_multilocular_lt_100mm": false,
                "solid_component_lt_7mm": false,
                "unilocular_cyst": false,
                "very_high_color_doppler": false
              }
            ]
          },
          "method": "POST",
          "type": "http"
        },
        "output": {
          "example": {
            "count": 2,
            "items": [
              {
                "b_count": 0,
                "citation": {
                  "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
                  "doi": "10.1002/uog.5365",
                  "id": "timmerman-2008",
                  "pmid": "18504770",
                  "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
                  "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
                },
                "classification": "malignant",
                "criteria": [
                  {
                    "factor": "irregular_solid_tumor",
                    "met": false
                  },
                  {
                    "factor": "ascites",
                    "met": true
                  },
                  {
                    "factor": "at_least_four_papillary_structures",
                    "met": false
                  },
                  {
                    "factor": "irregular_multilocular_solid_ge_100mm",
                    "met": false
                  },
                  {
                    "factor": "very_high_color_doppler",
                    "met": false
                  },
                  {
                    "factor": "unilocular_cyst",
                    "met": false
                  },
                  {
                    "factor": "solid_component_lt_7mm",
                    "met": false
                  },
                  {
                    "factor": "acoustic_shadows",
                    "met": false
                  },
                  {
                    "factor": "smooth_multilocular_lt_100mm",
                    "met": false
                  },
                  {
                    "factor": "no_detectable_blood_flow",
                    "met": false
                  }
                ],
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "formula": "iota",
                "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
                "m_count": 1
              },
              {
                "b_count": 0,
                "citation": {
                  "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
                  "doi": "10.1002/uog.5365",
                  "id": "timmerman-2008",
                  "pmid": "18504770",
                  "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
                  "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
                },
                "classification": "malignant",
                "criteria": [
                  {
                    "factor": "irregular_solid_tumor",
                    "met": false
                  },
                  {
                    "factor": "ascites",
                    "met": true
                  },
                  {
                    "factor": "at_least_four_papillary_structures",
                    "met": false
                  },
                  {
                    "factor": "irregular_multilocular_solid_ge_100mm",
                    "met": false
                  },
                  {
                    "factor": "very_high_color_doppler",
                    "met": false
                  },
                  {
                    "factor": "unilocular_cyst",
                    "met": false
                  },
                  {
                    "factor": "solid_component_lt_7mm",
                    "met": false
                  },
                  {
                    "factor": "acoustic_shadows",
                    "met": false
                  },
                  {
                    "factor": "smooth_multilocular_lt_100mm",
                    "met": false
                  },
                  {
                    "factor": "no_detectable_blood_flow",
                    "met": false
                  }
                ],
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "formula": "iota",
                "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
                "m_count": 1
              }
            ],
            "path": "/api/calc/iota"
          },
          "type": "json"
        }
      },
      "schema": {
        "$schema": "https://json-schema.org/draft/2020-12/schema",
        "properties": {
          "input": {
            "additionalProperties": false,
            "properties": {
              "body": {
                "additionalProperties": false,
                "properties": {
                  "items": {
                    "items": {
                      "properties": {
                        "acoustic_shadows": {
                          "description": "Acoustic shadows (B-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                          "type": "boolean"
                        },
                        "ascites": {
                          "description": "Ascites (M-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                          "type": "boolean"
                        },
                        "at_least_four_papillary_structures": {
                          "description": "At least four papillary structures (M-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                          "type": "boolean"
                        },
                        "irregular_multilocular_solid_ge_100mm": {
                          "description": "Irregular multilocular-solid tumor with largest diameter ≥100 mm (M-rule). true or false as assigned by the caller. magent does not measure the mass.",
                          "type": "boolean"
                        },
                        "irregular_solid_tumor": {
                          "description": "Irregular solid tumor (M-rule). true or false as assigned by the caller (Timmerman 2008). magent does not read ultrasound.",
                          "type": "boolean"
                        },
                        "no_detectable_blood_flow": {
                          "description": "No detectable blood flow on Doppler (B-rule). true or false as assigned by the caller. magent does not perform Doppler.",
                          "type": "boolean"
                        },
                        "smooth_multilocular_lt_100mm": {
                          "description": "Smooth multilocular tumor <100 mm largest diameter (B-rule). true or false as assigned by the caller. magent does not measure the mass.",
                          "type": "boolean"
                        },
                        "solid_component_lt_7mm": {
                          "description": "Solid components with largest solid component <7 mm (B-rule). true or false as assigned by the caller. magent does not measure the mass.",
                          "type": "boolean"
                        },
                        "unilocular_cyst": {
                          "description": "Unilocular cyst (B-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                          "type": "boolean"
                        },
                        "very_high_color_doppler": {
                          "description": "Very high color content on color Doppler (M-rule). true or false as assigned by the caller. magent does not perform Doppler.",
                          "type": "boolean"
                        }
                      },
                      "required": [
                        "irregular_solid_tumor",
                        "ascites",
                        "at_least_four_papillary_structures",
                        "irregular_multilocular_solid_ge_100mm",
                        "very_high_color_doppler",
                        "unilocular_cyst",
                        "solid_component_lt_7mm",
                        "acoustic_shadows",
                        "smooth_multilocular_lt_100mm",
                        "no_detectable_blood_flow"
                      ],
                      "type": "object"
                    },
                    "maxItems": 25,
                    "minItems": 1,
                    "type": "array"
                  }
                },
                "required": [
                  "items"
                ],
                "type": "object"
              },
              "headers": {
                "additionalProperties": {
                  "type": "string"
                },
                "type": "object"
              },
              "method": {
                "const": "POST",
                "type": "string"
              },
              "type": {
                "const": "http",
                "type": "string"
              }
            },
            "required": [
              "type",
              "method"
            ],
            "type": "object"
          },
          "output": {
            "properties": {
              "example": {
                "type": "object"
              },
              "type": {
                "type": "string"
              }
            },
            "required": [
              "type"
            ],
            "type": "object"
          }
        },
        "required": [
          "input"
        ],
        "type": "object"
      }
    }
  },
  "tags": [
    "iota",
    "ovarian",
    "ultrasound",
    "hematology",
    "simple-rules",
    "bazaar"
  ],
  "sourceHost": "api.magentlab.com",
  "lastUpdated": "2026-10-12T15:00:35.733Z",
  "quality": {
    "calls30d": 4,
    "uniquePayers30d": 2,
    "lastCalledAt": "2026-10-12T15:00:35.542Z"
  },
  "metadata": {
    "serviceName": "magent",
    "extensions": {
      "bazaar": {
        "info": {
          "iconUrl": "https://api.magentlab.com/favicon.ico",
          "input": {
            "body": {
              "items": [
                {
                  "acoustic_shadows": false,
                  "ascites": true,
                  "at_least_four_papillary_structures": false,
                  "irregular_multilocular_solid_ge_100mm": false,
                  "irregular_solid_tumor": false,
                  "no_detectable_blood_flow": false,
                  "smooth_multilocular_lt_100mm": false,
                  "solid_component_lt_7mm": false,
                  "unilocular_cyst": false,
                  "very_high_color_doppler": false
                },
                {
                  "acoustic_shadows": false,
                  "ascites": true,
                  "at_least_four_papillary_structures": false,
                  "irregular_multilocular_solid_ge_100mm": false,
                  "irregular_solid_tumor": false,
                  "no_detectable_blood_flow": false,
                  "smooth_multilocular_lt_100mm": false,
                  "solid_component_lt_7mm": false,
                  "unilocular_cyst": false,
                  "very_high_color_doppler": false
                }
              ]
            },
            "method": "POST",
            "type": "http"
          },
          "output": {
            "example": {
              "count": 2,
              "items": [
                {
                  "b_count": 0,
                  "citation": {
                    "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
                    "doi": "10.1002/uog.5365",
                    "id": "timmerman-2008",
                    "pmid": "18504770",
                    "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
                    "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
                  },
                  "classification": "malignant",
                  "criteria": [
                    {
                      "factor": "irregular_solid_tumor",
                      "met": false
                    },
                    {
                      "factor": "ascites",
                      "met": true
                    },
                    {
                      "factor": "at_least_four_papillary_structures",
                      "met": false
                    },
                    {
                      "factor": "irregular_multilocular_solid_ge_100mm",
                      "met": false
                    },
                    {
                      "factor": "very_high_color_doppler",
                      "met": false
                    },
                    {
                      "factor": "unilocular_cyst",
                      "met": false
                    },
                    {
                      "factor": "solid_component_lt_7mm",
                      "met": false
                    },
                    {
                      "factor": "acoustic_shadows",
                      "met": false
                    },
                    {
                      "factor": "smooth_multilocular_lt_100mm",
                      "met": false
                    },
                    {
                      "factor": "no_detectable_blood_flow",
                      "met": false
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "iota",
                  "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
                  "m_count": 1
                },
                {
                  "b_count": 0,
                  "citation": {
                    "authors": "Timmerman D, Testa AC, Bourne T, Ameye L, Jurkovic D, Van Holsbeke C, Paladini D, Van Calster B, Vergote I, Van Huffel S, Valentin L",
                    "doi": "10.1002/uog.5365",
                    "id": "timmerman-2008",
                    "pmid": "18504770",
                    "source": "Ultrasound Obstet Gynecol. 2008;31(6):681-690",
                    "title": "Simple ultrasound-based rules for the diagnosis of ovarian cancer."
                  },
                  "classification": "malignant",
                  "criteria": [
                    {
                      "factor": "irregular_solid_tumor",
                      "met": false
                    },
                    {
                      "factor": "ascites",
                      "met": true
                    },
                    {
                      "factor": "at_least_four_papillary_structures",
                      "met": false
                    },
                    {
                      "factor": "irregular_multilocular_solid_ge_100mm",
                      "met": false
                    },
                    {
                      "factor": "very_high_color_doppler",
                      "met": false
                    },
                    {
                      "factor": "unilocular_cyst",
                      "met": false
                    },
                    {
                      "factor": "solid_component_lt_7mm",
                      "met": false
                    },
                    {
                      "factor": "acoustic_shadows",
                      "met": false
                    },
                    {
                      "factor": "smooth_multilocular_lt_100mm",
                      "met": false
                    },
                    {
                      "factor": "no_detectable_blood_flow",
                      "met": false
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "iota",
                  "formula_expression": "classification malignant iff m_count >= 1 and b_count == 0; benign iff b_count >= 1 and m_count == 0; otherwise inconclusive; m_count counts irregular_solid_tumor, ascites, at_least_four_papillary_structures, irregular_multilocular_solid_ge_100mm, very_high_color_doppler; b_count counts unilocular_cyst, solid_component_lt_7mm, acoustic_shadows, smooth_multilocular_lt_100mm, no_detectable_blood_flow (Timmerman 2008 Simple Rules; not SRRisk)",
                  "m_count": 1
                }
              ],
              "path": "/api/calc/iota"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "body": {
                  "additionalProperties": false,
                  "properties": {
                    "items": {
                      "items": {
                        "properties": {
                          "acoustic_shadows": {
                            "description": "Acoustic shadows (B-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                            "type": "boolean"
                          },
                          "ascites": {
                            "description": "Ascites (M-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                            "type": "boolean"
                          },
                          "at_least_four_papillary_structures": {
                            "description": "At least four papillary structures (M-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                            "type": "boolean"
                          },
                          "irregular_multilocular_solid_ge_100mm": {
                            "description": "Irregular multilocular-solid tumor with largest diameter ≥100 mm (M-rule). true or false as assigned by the caller. magent does not measure the mass.",
                            "type": "boolean"
                          },
                          "irregular_solid_tumor": {
                            "description": "Irregular solid tumor (M-rule). true or false as assigned by the caller (Timmerman 2008). magent does not read ultrasound.",
                            "type": "boolean"
                          },
                          "no_detectable_blood_flow": {
                            "description": "No detectable blood flow on Doppler (B-rule). true or false as assigned by the caller. magent does not perform Doppler.",
                            "type": "boolean"
                          },
                          "smooth_multilocular_lt_100mm": {
                            "description": "Smooth multilocular tumor <100 mm largest diameter (B-rule). true or false as assigned by the caller. magent does not measure the mass.",
                            "type": "boolean"
                          },
                          "solid_component_lt_7mm": {
                            "description": "Solid components with largest solid component <7 mm (B-rule). true or false as assigned by the caller. magent does not measure the mass.",
                            "type": "boolean"
                          },
                          "unilocular_cyst": {
                            "description": "Unilocular cyst (B-rule). true or false as assigned by the caller. magent does not read ultrasound.",
                            "type": "boolean"
                          },
                          "very_high_color_doppler": {
                            "description": "Very high color content on color Doppler (M-rule). true or false as assigned by the caller. magent does not perform Doppler.",
                            "type": "boolean"
                          }
                        },
                        "required": [
                          "irregular_solid_tumor",
                          "ascites",
                          "at_least_four_papillary_structures",
                          "irregular_multilocular_solid_ge_100mm",
                          "very_high_color_doppler",
                          "unilocular_cyst",
                          "solid_component_lt_7mm",
                          "acoustic_shadows",
                          "smooth_multilocular_lt_100mm",
                          "no_detectable_blood_flow"
                        ],
                        "type": "object"
                      },
                      "maxItems": 25,
                      "minItems": 1,
                      "type": "array"
                    }
                  },
                  "required": [
                    "items"
                  ],
                  "type": "object"
                },
                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "type": "object"
                },
                "type": {
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
  }
}