Lee 2019 ASTCT CRS Table 1 grade 0-4

{
  "items": [
    {
      "fever": true,
      "fever_waived": false,
      "hypotension": "none",
      "hypoxia": "none"
    },
    {
      "fever": true,
      "fever_waived": false,
      "hypotension": "none",
      "hypoxia": "none"
    }
  ]
}

{
  "count": 2,
  "items": [
    {
      "citation": {
        "authors": "Lee DW, Santomasso BD, Locke FL, Ghobadi A, Turtle CJ, Brudno JN, Maus MV, Park JH, Mead E, Pavletic S, Go WY, Eldjerou L, Gardner RA, Frey N, Curran KJ, Peggs K, Pasquini M, DiPersio JF, van den Brink MRM, Komanduri KV, Grupp SA, Neelapu SS",
        "doi": "10.1016/j.bbmt.2018.12.758",
        "id": "lee-2019",
        "pmid": "30592986",
        "source": "Biol Blood Marrow Transplant. 2019;25(4):625-638",
        "title": "ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells"
      },
      "criteria": [
        {
          "factor": "fever_or_waived",
          "met": true
        },
        {
          "factor": "hypotension_none",
          "met": true,
          "value": "none"
        },
        {
          "factor": "hypotension_no_vasopressors",
          "met": false
        },
        {
          "factor": "hypotension_one_vasopressor",
          "met": false
        },
        {
          "factor": "hypotension_multiple_vasopressors",
          "met": false
        },
        {
          "factor": "hypoxia_none",
          "met": true,
          "value": "none"
        },
        {
          "factor": "hypoxia_low_flow",
          "met": false
        },
        {
          "factor": "hypoxia_high_flow",
          "met": false
        },
        {
          "factor": "hypoxia_positive_pressure",
          "met": false
        }
      ],
      "crs": true,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "fever": true,
      "fever_waived": false,
      "formula": "astct_crs",
      "formula_expression": "Lee 2019 ASTCT CRS Table 1. fever is temperature ≥38°C not attributable to another cause. fever_waived true if CRS already treated with antipyretic/tocilizumab/steroids so fever is no longer required. hypotension none | no_vasopressors | one_vasopressor (with or without vasopressin) | multiple_vasopressors (excluding vasopressin). hypoxia none | low_flow (≤6 L/min nasal cannula or blow-by) | high_flow (>6 L/min, facemask, NRB, or Venturi) | positive_pressure (CPAP/BiPAP/intubation). Grade is the more severe of hypotension vs hypoxia: both none → 1 if fever or fever_waived else 0 (crs false); no_vasopressors or low_flow → 2; one_vasopressor or high_flow → 3; multiple_vasopressors or positive_pressure → 4. Organ toxicities do not influence grade. Not ICANS",
      "grade": 1,
      "hypotension": "none",
      "hypotension_grade": 0,
      "hypoxia": "none",
      "hypoxia_grade": 0
    },
    {
      "citation": {
        "authors": "Lee DW, Santomasso BD, Locke FL, Ghobadi A, Turtle CJ, Brudno JN, Maus MV, Park JH, Mead E, Pavletic S, Go WY, Eldjerou L, Gardner RA, Frey N, Curran KJ, Peggs K, Pasquini M, DiPersio JF, van den Brink MRM, Komanduri KV, Grupp SA, Neelapu SS",
        "doi": "10.1016/j.bbmt.2018.12.758",
        "id": "lee-2019",
        "pmid": "30592986",
        "source": "Biol Blood Marrow Transplant. 2019;25(4):625-638",
        "title": "ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells"
      },
      "criteria": [
        {
          "factor": "fever_or_waived",
          "met": true
        },
        {
          "factor": "hypotension_none",
          "met": true,
          "value": "none"
        },
        {
          "factor": "hypotension_no_vasopressors",
          "met": false
        },
        {
          "factor": "hypotension_one_vasopressor",
          "met": false
        },
        {
          "factor": "hypotension_multiple_vasopressors",
          "met": false
        },
        {
          "factor": "hypoxia_none",
          "met": true,
          "value": "none"
        },
        {
          "factor": "hypoxia_low_flow",
          "met": false
        },
        {
          "factor": "hypoxia_high_flow",
          "met": false
        },
        {
          "factor": "hypoxia_positive_pressure",
          "met": false
        }
      ],
      "crs": true,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "fever": true,
      "fever_waived": false,
      "formula": "astct_crs",
      "formula_expression": "Lee 2019 ASTCT CRS Table 1. fever is temperature ≥38°C not attributable to another cause. fever_waived true if CRS already treated with antipyretic/tocilizumab/steroids so fever is no longer required. hypotension none | no_vasopressors | one_vasopressor (with or without vasopressin) | multiple_vasopressors (excluding vasopressin). hypoxia none | low_flow (≤6 L/min nasal cannula or blow-by) | high_flow (>6 L/min, facemask, NRB, or Venturi) | positive_pressure (CPAP/BiPAP/intubation). Grade is the more severe of hypotension vs hypoxia: both none → 1 if fever or fever_waived else 0 (crs false); no_vasopressors or low_flow → 2; one_vasopressor or high_flow → 3; multiple_vasopressors or positive_pressure → 4. Organ toxicities do not influence grade. Not ICANS",
      "grade": 1,
      "hypotension": "none",
      "hypotension_grade": 0,
      "hypoxia": "none",
      "hypoxia_grade": 0
    }
  ],
  "path": "/api/calc/astct_crs"
}