{
  "x402Version": 2,
  "id": 39427,
  "slug": "39427",
  "resource": "https://api.magentlab.com/api/calc/cll_ipi",
  "description": "CLL-IPI 2016 for chronic lymphocytic leukaemia: TP53 abnormality (del(17p) and/or TP53 mutation) 4, unmutated IGHV 2, beta-2 microglobulin >3.5 mg/L 2, advanced stage (Binet B/C or Rai I–IV) 1, age >65 1; max 10. Low 0–1, intermediate 2–3, high 4–6, very_high 7–10. Deterministic published score with citation; not a CLL diagnosis; not Shipp IPI; not MIPI. magent does not assay TP53, IGHV, or beta-2 microglobulin.",
  "type": "http",
  "serviceName": "magent",
  "resourceType": "Agent Service",
  "accepts": [
    {
      "scheme": "exact",
      "network": "eip155:8453",
      "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2",
      "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
      "amount": "5000",
      "amountUsd": 0.005,
      "maxTimeoutSeconds": 600
    }
  ],
  "outputSchema": {
    "properties": {
      "example": {
        "type": "object"
      },
      "type": {
        "type": "string"
      }
    },
    "required": [
      "type"
    ],
    "type": "object"
  },
  "extensions": {
    "bazaar": {
      "info": {
        "iconUrl": "https://api.magentlab.com/favicon.ico",
        "input": {
          "body": {
            "items": [
              {
                "advanced_stage": false,
                "age": 50,
                "beta2_microglobulin_mg_l": 2,
                "ighv_unmutated": false,
                "tp53_abnormal": false
              },
              {
                "advanced_stage": false,
                "age": 50,
                "beta2_microglobulin_mg_l": 2,
                "ighv_unmutated": false,
                "tp53_abnormal": false
              }
            ]
          },
          "method": "POST",
          "type": "http"
        },
        "output": {
          "example": {
            "count": 2,
            "items": [
              {
                "age_years": 50,
                "beta2_microglobulin_mg_l": 2,
                "citation": {
                  "authors": "The International CLL-IPI working group",
                  "doi": "10.1016/S1470-2045(16)30029-8",
                  "id": "cll-ipi-2016",
                  "pmid": "27153538",
                  "source": "Lancet Oncol. 2016;17(6):779-790",
                  "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
                },
                "components": [
                  {
                    "factor": "tp53_abnormal",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "ighv_unmutated",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "beta2_microglobulin_gt_3_5",
                    "points": 0,
                    "present": false,
                    "value": 2
                  },
                  {
                    "factor": "advanced_stage",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "age_gt_65",
                    "points": 0,
                    "present": false,
                    "value": 50
                  }
                ],
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "formula": "cll_ipi",
                "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
                "max_score": 10,
                "risk_group": "low",
                "score": 0
              },
              {
                "age_years": 50,
                "beta2_microglobulin_mg_l": 2,
                "citation": {
                  "authors": "The International CLL-IPI working group",
                  "doi": "10.1016/S1470-2045(16)30029-8",
                  "id": "cll-ipi-2016",
                  "pmid": "27153538",
                  "source": "Lancet Oncol. 2016;17(6):779-790",
                  "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
                },
                "components": [
                  {
                    "factor": "tp53_abnormal",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "ighv_unmutated",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "beta2_microglobulin_gt_3_5",
                    "points": 0,
                    "present": false,
                    "value": 2
                  },
                  {
                    "factor": "advanced_stage",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "age_gt_65",
                    "points": 0,
                    "present": false,
                    "value": 50
                  }
                ],
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "formula": "cll_ipi",
                "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
                "max_score": 10,
                "risk_group": "low",
                "score": 0
              }
            ],
            "path": "/api/calc/cll_ipi"
          },
          "type": "json"
        }
      },
      "schema": {
        "$schema": "https://json-schema.org/draft/2020-12/schema",
        "properties": {
          "input": {
            "additionalProperties": false,
            "properties": {
              "body": {
                "additionalProperties": false,
                "properties": {
                  "items": {
                    "items": {
                      "properties": {
                        "advanced_stage": {
                          "description": "Binet B/C or Rai I–IV as assigned by the caller (CLL-IPI 2016). true scores 1. false is Binet A / Rai 0. magent does not stage CLL.",
                          "type": "boolean"
                        },
                        "age": {
                          "description": "Age in years (18-120). Age >65 scores 1 (CLL-IPI 2016). Age 65 is the ≤65 arm and scores 0.",
                          "type": "integer"
                        },
                        "beta2_microglobulin_mg_l": {
                          "description": "Serum beta-2 microglobulin in mg/L (0.2-40). >3.5 scores 2 (CLL-IPI 2016). 3.5 is the ≤3.5 arm and scores 0. magent does not assay beta-2 microglobulin.",
                          "type": "number"
                        },
                        "ighv_unmutated": {
                          "description": "Unmutated IGHV as assigned by the caller (CLL-IPI 2016). true scores 2. magent does not sequence IGHV.",
                          "type": "boolean"
                        },
                        "tp53_abnormal": {
                          "description": "del(17p) and/or TP53 mutation as assigned by the caller (CLL-IPI 2016). true scores 4. magent does not assay TP53.",
                          "type": "boolean"
                        }
                      },
                      "required": [
                        "tp53_abnormal",
                        "ighv_unmutated",
                        "beta2_microglobulin_mg_l",
                        "advanced_stage",
                        "age"
                      ],
                      "type": "object"
                    },
                    "maxItems": 25,
                    "minItems": 1,
                    "type": "array"
                  }
                },
                "required": [
                  "items"
                ],
                "type": "object"
              },
              "headers": {
                "additionalProperties": {
                  "type": "string"
                },
                "type": "object"
              },
              "method": {
                "const": "POST",
                "type": "string"
              },
              "type": {
                "const": "http",
                "type": "string"
              }
            },
            "required": [
              "type",
              "method"
            ],
            "type": "object"
          },
          "output": {
            "properties": {
              "example": {
                "type": "object"
              },
              "type": {
                "type": "string"
              }
            },
            "required": [
              "type"
            ],
            "type": "object"
          }
        },
        "required": [
          "input"
        ],
        "type": "object"
      }
    }
  },
  "tags": [
    "cll-ipi",
    "cll",
    "hematology",
    "prognosis",
    "calculator",
    "bazaar"
  ],
  "sourceHost": "api.magentlab.com",
  "lastUpdated": "2026-10-12T14:54:40.096Z",
  "quality": {
    "calls30d": 4,
    "uniquePayers30d": 2,
    "lastCalledAt": "2026-10-12T14:54:39.97Z"
  },
  "metadata": {
    "serviceName": "magent",
    "extensions": {
      "bazaar": {
        "info": {
          "iconUrl": "https://api.magentlab.com/favicon.ico",
          "input": {
            "body": {
              "items": [
                {
                  "advanced_stage": false,
                  "age": 50,
                  "beta2_microglobulin_mg_l": 2,
                  "ighv_unmutated": false,
                  "tp53_abnormal": false
                },
                {
                  "advanced_stage": false,
                  "age": 50,
                  "beta2_microglobulin_mg_l": 2,
                  "ighv_unmutated": false,
                  "tp53_abnormal": false
                }
              ]
            },
            "method": "POST",
            "type": "http"
          },
          "output": {
            "example": {
              "count": 2,
              "items": [
                {
                  "age_years": 50,
                  "beta2_microglobulin_mg_l": 2,
                  "citation": {
                    "authors": "The International CLL-IPI working group",
                    "doi": "10.1016/S1470-2045(16)30029-8",
                    "id": "cll-ipi-2016",
                    "pmid": "27153538",
                    "source": "Lancet Oncol. 2016;17(6):779-790",
                    "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
                  },
                  "components": [
                    {
                      "factor": "tp53_abnormal",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "ighv_unmutated",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "beta2_microglobulin_gt_3_5",
                      "points": 0,
                      "present": false,
                      "value": 2
                    },
                    {
                      "factor": "advanced_stage",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "age_gt_65",
                      "points": 0,
                      "present": false,
                      "value": 50
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "cll_ipi",
                  "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
                  "max_score": 10,
                  "risk_group": "low",
                  "score": 0
                },
                {
                  "age_years": 50,
                  "beta2_microglobulin_mg_l": 2,
                  "citation": {
                    "authors": "The International CLL-IPI working group",
                    "doi": "10.1016/S1470-2045(16)30029-8",
                    "id": "cll-ipi-2016",
                    "pmid": "27153538",
                    "source": "Lancet Oncol. 2016;17(6):779-790",
                    "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
                  },
                  "components": [
                    {
                      "factor": "tp53_abnormal",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "ighv_unmutated",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "beta2_microglobulin_gt_3_5",
                      "points": 0,
                      "present": false,
                      "value": 2
                    },
                    {
                      "factor": "advanced_stage",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "age_gt_65",
                      "points": 0,
                      "present": false,
                      "value": 50
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "cll_ipi",
                  "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
                  "max_score": 10,
                  "risk_group": "low",
                  "score": 0
                }
              ],
              "path": "/api/calc/cll_ipi"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "body": {
                  "additionalProperties": false,
                  "properties": {
                    "items": {
                      "items": {
                        "properties": {
                          "advanced_stage": {
                            "description": "Binet B/C or Rai I–IV as assigned by the caller (CLL-IPI 2016). true scores 1. false is Binet A / Rai 0. magent does not stage CLL.",
                            "type": "boolean"
                          },
                          "age": {
                            "description": "Age in years (18-120). Age >65 scores 1 (CLL-IPI 2016). Age 65 is the ≤65 arm and scores 0.",
                            "type": "integer"
                          },
                          "beta2_microglobulin_mg_l": {
                            "description": "Serum beta-2 microglobulin in mg/L (0.2-40). >3.5 scores 2 (CLL-IPI 2016). 3.5 is the ≤3.5 arm and scores 0. magent does not assay beta-2 microglobulin.",
                            "type": "number"
                          },
                          "ighv_unmutated": {
                            "description": "Unmutated IGHV as assigned by the caller (CLL-IPI 2016). true scores 2. magent does not sequence IGHV.",
                            "type": "boolean"
                          },
                          "tp53_abnormal": {
                            "description": "del(17p) and/or TP53 mutation as assigned by the caller (CLL-IPI 2016). true scores 4. magent does not assay TP53.",
                            "type": "boolean"
                          }
                        },
                        "required": [
                          "tp53_abnormal",
                          "ighv_unmutated",
                          "beta2_microglobulin_mg_l",
                          "advanced_stage",
                          "age"
                        ],
                        "type": "object"
                      },
                      "maxItems": 25,
                      "minItems": 1,
                      "type": "array"
                    }
                  },
                  "required": [
                    "items"
                  ],
                  "type": "object"
                },
                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "type": "object"
                },
                "type": {
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
  }
}