{
  "x402Version": 2,
  "id": 39511,
  "slug": "39511",
  "resource": "https://api.magentlab.com/api/calc/myeloma_iss",
  "description": "Greipp 2005 International Staging System for multiple myeloma. Stage I: serum beta-2 microglobulin <3.5 mg/L and albumin >=3.5 g/dL. Stage III: beta-2 microglobulin >=5.5 mg/L. Stage II: neither I nor III. Returns iss_stage 1/2/3. Not a myeloma diagnosis or treatment choice; not R-ISS (no LDH, no cytogenetics); not trauma ISS. magent does not assay beta-2 microglobulin or albumin.",
  "type": "http",
  "serviceName": "magent",
  "resourceType": "Agent Service",
  "accepts": [
    {
      "scheme": "exact",
      "network": "eip155:8453",
      "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2",
      "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
      "amount": "5000",
      "amountUsd": 0.005,
      "maxTimeoutSeconds": 600
    }
  ],
  "outputSchema": {
    "properties": {
      "example": {
        "type": "object"
      },
      "type": {
        "type": "string"
      }
    },
    "required": [
      "type"
    ],
    "type": "object"
  },
  "extensions": {
    "bazaar": {
      "info": {
        "iconUrl": "https://api.magentlab.com/favicon.ico",
        "input": {
          "body": {
            "items": [
              {
                "albumin_g_dl": 4,
                "albumin_g_l": 40,
                "beta2_microglobulin_mg_l": 2
              },
              {
                "albumin_g_dl": 4,
                "albumin_g_l": 40,
                "beta2_microglobulin_mg_l": 2
              }
            ]
          },
          "method": "POST",
          "type": "http"
        },
        "output": {
          "example": {
            "count": 2,
            "items": [
              {
                "albumin_g_dl": 4,
                "beta2_microglobulin_mg_l": 2,
                "citation": {
                  "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
                  "doi": "10.1200/JCO.2005.04.242",
                  "id": "greipp-2005",
                  "pmid": "15809451",
                  "source": "J Clin Oncol. 2005;23(15):3412-3420",
                  "title": "International staging system for multiple myeloma"
                },
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "formula": "myeloma_iss",
                "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
                "iss_stage": 1,
                "iss_stage_label": "I"
              },
              {
                "albumin_g_dl": 4,
                "beta2_microglobulin_mg_l": 2,
                "citation": {
                  "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
                  "doi": "10.1200/JCO.2005.04.242",
                  "id": "greipp-2005",
                  "pmid": "15809451",
                  "source": "J Clin Oncol. 2005;23(15):3412-3420",
                  "title": "International staging system for multiple myeloma"
                },
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "formula": "myeloma_iss",
                "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
                "iss_stage": 1,
                "iss_stage_label": "I"
              }
            ],
            "path": "/api/calc/myeloma_iss"
          },
          "type": "json"
        }
      },
      "schema": {
        "$schema": "https://json-schema.org/draft/2020-12/schema",
        "properties": {
          "input": {
            "additionalProperties": false,
            "properties": {
              "body": {
                "additionalProperties": false,
                "properties": {
                  "items": {
                    "items": {
                      "properties": {
                        "albumin_g_dl": {
                          "description": "Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. Greipp 2005 stages use g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5.",
                          "type": "number"
                        },
                        "albumin_g_l": {
                          "description": "Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both.",
                          "type": "number"
                        },
                        "beta2_microglobulin_mg_l": {
                          "description": "Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 Sβ2M. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin.",
                          "type": "number"
                        }
                      },
                      "required": [
                        "beta2_microglobulin_mg_l"
                      ],
                      "type": "object"
                    },
                    "maxItems": 25,
                    "minItems": 1,
                    "type": "array"
                  }
                },
                "required": [
                  "items"
                ],
                "type": "object"
              },
              "headers": {
                "additionalProperties": {
                  "type": "string"
                },
                "type": "object"
              },
              "method": {
                "const": "POST",
                "type": "string"
              },
              "type": {
                "const": "http",
                "type": "string"
              }
            },
            "required": [
              "type",
              "method"
            ],
            "type": "object"
          },
          "output": {
            "properties": {
              "example": {
                "type": "object"
              },
              "type": {
                "type": "string"
              }
            },
            "required": [
              "type"
            ],
            "type": "object"
          }
        },
        "required": [
          "input"
        ],
        "type": "object"
      }
    }
  },
  "tags": [
    "myeloma-iss",
    "myeloma",
    "hematology",
    "staging",
    "calculator",
    "bazaar"
  ],
  "sourceHost": "api.magentlab.com",
  "lastUpdated": "2026-10-12T14:58:17.752Z",
  "quality": {
    "calls30d": 3,
    "uniquePayers30d": 1,
    "lastCalledAt": "2026-10-12T14:58:17.621Z"
  },
  "metadata": {
    "serviceName": "magent",
    "extensions": {
      "bazaar": {
        "info": {
          "iconUrl": "https://api.magentlab.com/favicon.ico",
          "input": {
            "body": {
              "items": [
                {
                  "albumin_g_dl": 4,
                  "albumin_g_l": 40,
                  "beta2_microglobulin_mg_l": 2
                },
                {
                  "albumin_g_dl": 4,
                  "albumin_g_l": 40,
                  "beta2_microglobulin_mg_l": 2
                }
              ]
            },
            "method": "POST",
            "type": "http"
          },
          "output": {
            "example": {
              "count": 2,
              "items": [
                {
                  "albumin_g_dl": 4,
                  "beta2_microglobulin_mg_l": 2,
                  "citation": {
                    "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
                    "doi": "10.1200/JCO.2005.04.242",
                    "id": "greipp-2005",
                    "pmid": "15809451",
                    "source": "J Clin Oncol. 2005;23(15):3412-3420",
                    "title": "International staging system for multiple myeloma"
                  },
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "myeloma_iss",
                  "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
                  "iss_stage": 1,
                  "iss_stage_label": "I"
                },
                {
                  "albumin_g_dl": 4,
                  "beta2_microglobulin_mg_l": 2,
                  "citation": {
                    "authors": "Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J",
                    "doi": "10.1200/JCO.2005.04.242",
                    "id": "greipp-2005",
                    "pmid": "15809451",
                    "source": "J Clin Oncol. 2005;23(15):3412-3420",
                    "title": "International staging system for multiple myeloma"
                  },
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "myeloma_iss",
                  "formula_expression": "ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)",
                  "iss_stage": 1,
                  "iss_stage_label": "I"
                }
              ],
              "path": "/api/calc/myeloma_iss"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "body": {
                  "additionalProperties": false,
                  "properties": {
                    "items": {
                      "items": {
                        "properties": {
                          "albumin_g_dl": {
                            "description": "Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. Greipp 2005 stages use g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5.",
                            "type": "number"
                          },
                          "albumin_g_l": {
                            "description": "Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both.",
                            "type": "number"
                          },
                          "beta2_microglobulin_mg_l": {
                            "description": "Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 Sβ2M. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin.",
                            "type": "number"
                          }
                        },
                        "required": [
                          "beta2_microglobulin_mg_l"
                        ],
                        "type": "object"
                      },
                      "maxItems": 25,
                      "minItems": 1,
                      "type": "array"
                    }
                  },
                  "required": [
                    "items"
                  ],
                  "type": "object"
                },
                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "type": "object"
                },
                "type": {
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
  }
}