{
  "x402Version": 2,
  "id": 39513,
  "slug": "39513",
  "resource": "https://api.magentlab.com/api/calc/mipss70",
  "description": "Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.",
  "type": "http",
  "serviceName": "magent",
  "resourceType": "Agent Service",
  "accepts": [
    {
      "scheme": "exact",
      "network": "eip155:8453",
      "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2",
      "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
      "amount": "5000",
      "amountUsd": 0.005,
      "maxTimeoutSeconds": 600
    }
  ],
  "outputSchema": {
    "properties": {
      "example": {
        "type": "object"
      },
      "type": {
        "type": "string"
      }
    },
    "required": [
      "type"
    ],
    "type": "object"
  },
  "extensions": {
    "bazaar": {
      "info": {
        "iconUrl": "https://api.magentlab.com/favicon.ico",
        "input": {
          "body": {
            "items": [
              {
                "blasts_percent": 0,
                "calr_type1_like": true,
                "constitutional_symptoms": false,
                "fibrosis_grade": 1,
                "hemoglobin_g_dl": 12,
                "hemoglobin_g_l": 120,
                "hmr_mutation_count": 0,
                "leukocytes_10e9_l": 10,
                "platelets_10e9_l": 200
              },
              {
                "blasts_percent": 0,
                "calr_type1_like": true,
                "constitutional_symptoms": false,
                "fibrosis_grade": 1,
                "hemoglobin_g_dl": 12,
                "hemoglobin_g_l": 120,
                "hmr_mutation_count": 0,
                "leukocytes_10e9_l": 10,
                "platelets_10e9_l": 200
              }
            ]
          },
          "method": "POST",
          "type": "http"
        },
        "output": {
          "example": {
            "count": 2,
            "items": [
              {
                "blasts_percent": 0,
                "calr_type1_like": true,
                "citation": {
                  "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
                  "doi": "10.1200/JCO.2017.76.4886",
                  "id": "guglielmelli-2018",
                  "pmid": "29226763",
                  "source": "J Clin Oncol. 2018;36(4):310-318",
                  "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
                },
                "components": [
                  {
                    "factor": "hemoglobin_lt_10",
                    "points": 0,
                    "present": false,
                    "value": 12
                  },
                  {
                    "factor": "leukocytes_gt_25",
                    "points": 0,
                    "present": false,
                    "value": 10
                  },
                  {
                    "factor": "platelets_lt_100",
                    "points": 0,
                    "present": false,
                    "value": 200
                  },
                  {
                    "factor": "blasts_ge_2",
                    "points": 0,
                    "present": false,
                    "value": 0
                  },
                  {
                    "factor": "fibrosis_ge_2",
                    "points": 0,
                    "present": false,
                    "value": 1
                  },
                  {
                    "factor": "constitutional_symptoms",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "absence_of_calr_type1_like",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "hmr_category",
                    "points": 0,
                    "present": false,
                    "value": 0
                  },
                  {
                    "factor": "hmr_two_or_more",
                    "points": 0,
                    "present": false,
                    "value": 0
                  }
                ],
                "constitutional_symptoms": false,
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "fibrosis_grade": 1,
                "five_year_survival_percent": 95,
                "formula": "mipss70",
                "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
                "hemoglobin_g_dl": 12,
                "hmr_mutation_count": 0,
                "leukocytes_10e9_l": 10,
                "max_score": 12,
                "median_survival_years": 27.7,
                "platelets_10e9_l": 200,
                "risk_band": "low",
                "score": 0
              },
              {
                "blasts_percent": 0,
                "calr_type1_like": true,
                "citation": {
                  "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
                  "doi": "10.1200/JCO.2017.76.4886",
                  "id": "guglielmelli-2018",
                  "pmid": "29226763",
                  "source": "J Clin Oncol. 2018;36(4):310-318",
                  "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
                },
                "components": [
                  {
                    "factor": "hemoglobin_lt_10",
                    "points": 0,
                    "present": false,
                    "value": 12
                  },
                  {
                    "factor": "leukocytes_gt_25",
                    "points": 0,
                    "present": false,
                    "value": 10
                  },
                  {
                    "factor": "platelets_lt_100",
                    "points": 0,
                    "present": false,
                    "value": 200
                  },
                  {
                    "factor": "blasts_ge_2",
                    "points": 0,
                    "present": false,
                    "value": 0
                  },
                  {
                    "factor": "fibrosis_ge_2",
                    "points": 0,
                    "present": false,
                    "value": 1
                  },
                  {
                    "factor": "constitutional_symptoms",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "absence_of_calr_type1_like",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "hmr_category",
                    "points": 0,
                    "present": false,
                    "value": 0
                  },
                  {
                    "factor": "hmr_two_or_more",
                    "points": 0,
                    "present": false,
                    "value": 0
                  }
                ],
                "constitutional_symptoms": false,
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "fibrosis_grade": 1,
                "five_year_survival_percent": 95,
                "formula": "mipss70",
                "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
                "hemoglobin_g_dl": 12,
                "hmr_mutation_count": 0,
                "leukocytes_10e9_l": 10,
                "max_score": 12,
                "median_survival_years": 27.7,
                "platelets_10e9_l": 200,
                "risk_band": "low",
                "score": 0
              }
            ],
            "path": "/api/calc/mipss70"
          },
          "type": "json"
        }
      },
      "schema": {
        "$schema": "https://json-schema.org/draft/2020-12/schema",
        "properties": {
          "input": {
            "additionalProperties": false,
            "properties": {
              "body": {
                "additionalProperties": false,
                "properties": {
                  "items": {
                    "items": {
                      "properties": {
                        "blasts_percent": {
                          "description": "Circulating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear.",
                          "type": "number"
                        },
                        "calr_type1_like": {
                          "description": "Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence.",
                          "type": "boolean"
                        },
                        "constitutional_symptoms": {
                          "description": "Constitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history.",
                          "type": "boolean"
                        },
                        "fibrosis_grade": {
                          "description": "WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow.",
                          "type": "integer"
                        },
                        "hemoglobin_g_dl": {
                          "description": "Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin.",
                          "type": "number"
                        },
                        "hemoglobin_g_l": {
                          "description": "Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0.",
                          "type": "number"
                        },
                        "hmr_mutation_count": {
                          "description": "Count of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). ≥1 scores 1 (HMR category). ≥2 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence.",
                          "type": "integer"
                        },
                        "leukocytes_10e9_l": {
                          "description": "Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes.",
                          "type": "number"
                        },
                        "platelets_10e9_l": {
                          "description": "Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets.",
                          "type": "number"
                        }
                      },
                      "required": [
                        "leukocytes_10e9_l",
                        "platelets_10e9_l",
                        "blasts_percent",
                        "fibrosis_grade",
                        "constitutional_symptoms",
                        "calr_type1_like",
                        "hmr_mutation_count"
                      ],
                      "type": "object"
                    },
                    "maxItems": 25,
                    "minItems": 1,
                    "type": "array"
                  }
                },
                "required": [
                  "items"
                ],
                "type": "object"
              },
              "headers": {
                "additionalProperties": {
                  "type": "string"
                },
                "type": "object"
              },
              "method": {
                "const": "POST",
                "type": "string"
              },
              "type": {
                "const": "http",
                "type": "string"
              }
            },
            "required": [
              "type",
              "method"
            ],
            "type": "object"
          },
          "output": {
            "properties": {
              "example": {
                "type": "object"
              },
              "type": {
                "type": "string"
              }
            },
            "required": [
              "type"
            ],
            "type": "object"
          }
        },
        "required": [
          "input"
        ],
        "type": "object"
      }
    }
  },
  "tags": [
    "mipss70",
    "myelofibrosis",
    "hematology",
    "prognosis",
    "pmf",
    "bazaar"
  ],
  "sourceHost": "api.magentlab.com",
  "lastUpdated": "2026-10-12T14:55:56.021Z",
  "quality": {
    "calls30d": 3,
    "uniquePayers30d": 1,
    "lastCalledAt": "2026-10-12T14:55:55.884Z"
  },
  "metadata": {
    "serviceName": "magent",
    "extensions": {
      "bazaar": {
        "info": {
          "iconUrl": "https://api.magentlab.com/favicon.ico",
          "input": {
            "body": {
              "items": [
                {
                  "blasts_percent": 0,
                  "calr_type1_like": true,
                  "constitutional_symptoms": false,
                  "fibrosis_grade": 1,
                  "hemoglobin_g_dl": 12,
                  "hemoglobin_g_l": 120,
                  "hmr_mutation_count": 0,
                  "leukocytes_10e9_l": 10,
                  "platelets_10e9_l": 200
                },
                {
                  "blasts_percent": 0,
                  "calr_type1_like": true,
                  "constitutional_symptoms": false,
                  "fibrosis_grade": 1,
                  "hemoglobin_g_dl": 12,
                  "hemoglobin_g_l": 120,
                  "hmr_mutation_count": 0,
                  "leukocytes_10e9_l": 10,
                  "platelets_10e9_l": 200
                }
              ]
            },
            "method": "POST",
            "type": "http"
          },
          "output": {
            "example": {
              "count": 2,
              "items": [
                {
                  "blasts_percent": 0,
                  "calr_type1_like": true,
                  "citation": {
                    "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
                    "doi": "10.1200/JCO.2017.76.4886",
                    "id": "guglielmelli-2018",
                    "pmid": "29226763",
                    "source": "J Clin Oncol. 2018;36(4):310-318",
                    "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
                  },
                  "components": [
                    {
                      "factor": "hemoglobin_lt_10",
                      "points": 0,
                      "present": false,
                      "value": 12
                    },
                    {
                      "factor": "leukocytes_gt_25",
                      "points": 0,
                      "present": false,
                      "value": 10
                    },
                    {
                      "factor": "platelets_lt_100",
                      "points": 0,
                      "present": false,
                      "value": 200
                    },
                    {
                      "factor": "blasts_ge_2",
                      "points": 0,
                      "present": false,
                      "value": 0
                    },
                    {
                      "factor": "fibrosis_ge_2",
                      "points": 0,
                      "present": false,
                      "value": 1
                    },
                    {
                      "factor": "constitutional_symptoms",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "absence_of_calr_type1_like",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "hmr_category",
                      "points": 0,
                      "present": false,
                      "value": 0
                    },
                    {
                      "factor": "hmr_two_or_more",
                      "points": 0,
                      "present": false,
                      "value": 0
                    }
                  ],
                  "constitutional_symptoms": false,
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "fibrosis_grade": 1,
                  "five_year_survival_percent": 95,
                  "formula": "mipss70",
                  "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
                  "hemoglobin_g_dl": 12,
                  "hmr_mutation_count": 0,
                  "leukocytes_10e9_l": 10,
                  "max_score": 12,
                  "median_survival_years": 27.7,
                  "platelets_10e9_l": 200,
                  "risk_band": "low",
                  "score": 0
                },
                {
                  "blasts_percent": 0,
                  "calr_type1_like": true,
                  "citation": {
                    "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
                    "doi": "10.1200/JCO.2017.76.4886",
                    "id": "guglielmelli-2018",
                    "pmid": "29226763",
                    "source": "J Clin Oncol. 2018;36(4):310-318",
                    "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
                  },
                  "components": [
                    {
                      "factor": "hemoglobin_lt_10",
                      "points": 0,
                      "present": false,
                      "value": 12
                    },
                    {
                      "factor": "leukocytes_gt_25",
                      "points": 0,
                      "present": false,
                      "value": 10
                    },
                    {
                      "factor": "platelets_lt_100",
                      "points": 0,
                      "present": false,
                      "value": 200
                    },
                    {
                      "factor": "blasts_ge_2",
                      "points": 0,
                      "present": false,
                      "value": 0
                    },
                    {
                      "factor": "fibrosis_ge_2",
                      "points": 0,
                      "present": false,
                      "value": 1
                    },
                    {
                      "factor": "constitutional_symptoms",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "absence_of_calr_type1_like",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "hmr_category",
                      "points": 0,
                      "present": false,
                      "value": 0
                    },
                    {
                      "factor": "hmr_two_or_more",
                      "points": 0,
                      "present": false,
                      "value": 0
                    }
                  ],
                  "constitutional_symptoms": false,
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "fibrosis_grade": 1,
                  "five_year_survival_percent": 95,
                  "formula": "mipss70",
                  "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
                  "hemoglobin_g_dl": 12,
                  "hmr_mutation_count": 0,
                  "leukocytes_10e9_l": 10,
                  "max_score": 12,
                  "median_survival_years": 27.7,
                  "platelets_10e9_l": 200,
                  "risk_band": "low",
                  "score": 0
                }
              ],
              "path": "/api/calc/mipss70"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "body": {
                  "additionalProperties": false,
                  "properties": {
                    "items": {
                      "items": {
                        "properties": {
                          "blasts_percent": {
                            "description": "Circulating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear.",
                            "type": "number"
                          },
                          "calr_type1_like": {
                            "description": "Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence.",
                            "type": "boolean"
                          },
                          "constitutional_symptoms": {
                            "description": "Constitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history.",
                            "type": "boolean"
                          },
                          "fibrosis_grade": {
                            "description": "WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow.",
                            "type": "integer"
                          },
                          "hemoglobin_g_dl": {
                            "description": "Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin.",
                            "type": "number"
                          },
                          "hemoglobin_g_l": {
                            "description": "Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0.",
                            "type": "number"
                          },
                          "hmr_mutation_count": {
                            "description": "Count of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). ≥1 scores 1 (HMR category). ≥2 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence.",
                            "type": "integer"
                          },
                          "leukocytes_10e9_l": {
                            "description": "Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes.",
                            "type": "number"
                          },
                          "platelets_10e9_l": {
                            "description": "Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets.",
                            "type": "number"
                          }
                        },
                        "required": [
                          "leukocytes_10e9_l",
                          "platelets_10e9_l",
                          "blasts_percent",
                          "fibrosis_grade",
                          "constitutional_symptoms",
                          "calr_type1_like",
                          "hmr_mutation_count"
                        ],
                        "type": "object"
                      },
                      "maxItems": 25,
                      "minItems": 1,
                      "type": "array"
                    }
                  },
                  "required": [
                    "items"
                  ],
                  "type": "object"
                },
                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "type": "object"
                },
                "type": {
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
  }
}