{
  "x402Version": 2,
  "id": 39548,
  "slug": "39548",
  "resource": "https://api.magentlab.com/api/calc/dutch_fh",
  "description": "Dutch Lipid Clinic Network (Nordestgaard 2013 Table 1) familial hypercholesterolaemia score. One LDL (mmol/L or mg/dL / 38.67) plus family, clinical, physical, and DNA groups; per group only the highest. Max 26. Definite >8, probable 6-8, possible 3-5, unlikely 0-2. Score 8 (mutation alone) is probable. Adult Table 1 only; not Simon Broome, not MEDPED, not homozygous FH. magent does not assay lipids, examine tendons or arcus, or sequence genes. Not a medical device and not a diagnosis of FH.",
  "type": "http",
  "serviceName": "magent",
  "resourceType": "Agent Service",
  "accepts": [
    {
      "scheme": "exact",
      "network": "eip155:8453",
      "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2",
      "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
      "amount": "5000",
      "amountUsd": 0.005,
      "maxTimeoutSeconds": 600
    }
  ],
  "outputSchema": {
    "properties": {
      "example": {
        "type": "object"
      },
      "type": {
        "type": "string"
      }
    },
    "required": [
      "type"
    ],
    "type": "object"
  },
  "extensions": {
    "bazaar": {
      "info": {
        "iconUrl": "https://api.magentlab.com/favicon.ico",
        "input": {
          "body": {
            "items": [
              {
                "causative_mutation_ldlr_apob_pcsk9": false,
                "child_ldl_gt_95th": false,
                "corneal_arcus_age_lt_45": false,
                "first_degree_ldl_gt_95th": false,
                "first_degree_premature_chd": false,
                "first_degree_xanthoma_or_arcus": false,
                "ldl_mg_dl": 348,
                "ldl_mmol_l": 9,
                "premature_cerebral_or_pvd": false,
                "premature_chd": false,
                "tendon_xanthoma": true
              },
              {
                "causative_mutation_ldlr_apob_pcsk9": false,
                "child_ldl_gt_95th": false,
                "corneal_arcus_age_lt_45": false,
                "first_degree_ldl_gt_95th": false,
                "first_degree_premature_chd": false,
                "first_degree_xanthoma_or_arcus": false,
                "ldl_mg_dl": 348,
                "ldl_mmol_l": 9,
                "premature_cerebral_or_pvd": false,
                "premature_chd": false,
                "tendon_xanthoma": true
              }
            ]
          },
          "method": "POST",
          "type": "http"
        },
        "output": {
          "example": {
            "count": 2,
            "items": [
              {
                "citation": {
                  "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
                  "doi": "10.1093/eurheartj/eht273",
                  "id": "nordestgaard-2013",
                  "pmid": "23956253",
                  "source": "Eur Heart J. 2013;34(45):3478-3490",
                  "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
                },
                "classification": "definite",
                "clinical_points": 0,
                "components": [
                  {
                    "factor": "family",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "clinical",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "physical",
                    "points": 6,
                    "present": true
                  },
                  {
                    "factor": "ldl",
                    "points": 8,
                    "present": true,
                    "value": 9
                  },
                  {
                    "factor": "dna",
                    "points": 0,
                    "present": false
                  }
                ],
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "dna_points": 0,
                "family_points": 0,
                "formula": "dutch_fh",
                "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
                "ldl_mmol_l": 9,
                "ldl_points": 8,
                "max_score": 26,
                "physical_points": 6,
                "score": 14
              },
              {
                "citation": {
                  "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
                  "doi": "10.1093/eurheartj/eht273",
                  "id": "nordestgaard-2013",
                  "pmid": "23956253",
                  "source": "Eur Heart J. 2013;34(45):3478-3490",
                  "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
                },
                "classification": "definite",
                "clinical_points": 0,
                "components": [
                  {
                    "factor": "family",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "clinical",
                    "points": 0,
                    "present": false
                  },
                  {
                    "factor": "physical",
                    "points": 6,
                    "present": true
                  },
                  {
                    "factor": "ldl",
                    "points": 8,
                    "present": true,
                    "value": 9
                  },
                  {
                    "factor": "dna",
                    "points": 0,
                    "present": false
                  }
                ],
                "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                "dna_points": 0,
                "family_points": 0,
                "formula": "dutch_fh",
                "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
                "ldl_mmol_l": 9,
                "ldl_points": 8,
                "max_score": 26,
                "physical_points": 6,
                "score": 14
              }
            ],
            "path": "/api/calc/dutch_fh"
          },
          "type": "json"
        }
      },
      "schema": {
        "$schema": "https://json-schema.org/draft/2020-12/schema",
        "properties": {
          "input": {
            "additionalProperties": false,
            "properties": {
              "body": {
                "additionalProperties": false,
                "properties": {
                  "items": {
                    "items": {
                      "properties": {
                        "causative_mutation_ldlr_apob_pcsk9": {
                          "description": "Causative mutation in LDLR, APOB, or PCSK9 as assigned by the caller (Nordestgaard 2013 Table 1 DNA analysis, 8 points). true or false. magent does not sequence genes. Mutation alone is probable (score 8), not definite.",
                          "type": "boolean"
                        },
                        "child_ldl_gt_95th": {
                          "description": "Child under 18 years with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.",
                          "type": "boolean"
                        },
                        "corneal_arcus_age_lt_45": {
                          "description": "Arcus cornealis before age 45 years (Nordestgaard 2013 Table 1 physical examination, 4 points). true or false as assigned by the caller. magent does not examine the cornea or compute age.",
                          "type": "boolean"
                        },
                        "first_degree_ldl_gt_95th": {
                          "description": "First-degree relative with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.",
                          "type": "boolean"
                        },
                        "first_degree_premature_chd": {
                          "description": "First-degree relative with premature coronary heart disease (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not take a pedigree. Either this or first_degree_ldl_gt_95th scores 1 for the family group; a 2-point family item still yields family 2, not 3.",
                          "type": "boolean"
                        },
                        "first_degree_xanthoma_or_arcus": {
                          "description": "First-degree relative with tendon xanthoma and/or arcus cornealis (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not examine relatives. Either this or child_ldl_gt_95th scores 2 for the family group (max of family items).",
                          "type": "boolean"
                        },
                        "ldl_mg_dl": {
                          "description": "LDL cholesterol in mg/dL (40-800). Converted to mmol/L as mg/dL / 38.67, then scored on the mmol/L bands. Provide exactly one lipid parameter.",
                          "type": "number"
                        },
                        "ldl_mmol_l": {
                          "description": "LDL cholesterol in mmol/L (1-20). Nordestgaard 2013 Table 1 bands: >8.5 → 8, 6.5-8.4 → 5, 5.0-6.4 → 3, 4.0-4.9 → 1. Provide exactly one of ldl_mmol_l or ldl_mg_dl. magent does not assay lipids.",
                          "type": "number"
                        },
                        "premature_cerebral_or_pvd": {
                          "description": "Premature cerebral or peripheral vascular disease in the subject (Nordestgaard 2013 Table 1 clinical history, 1 point). true or false as assigned by the caller. magent does not diagnose vascular disease.",
                          "type": "boolean"
                        },
                        "premature_chd": {
                          "description": "Premature coronary heart disease in the subject (Nordestgaard 2013 Table 1 clinical history, 2 points; men <55 years / women <60 years as assigned by the caller). true or false. magent does not diagnose CHD or compute age or sex. If premature_cerebral_or_pvd is also true, the clinical group is 2, not 3.",
                          "type": "boolean"
                        },
                        "tendon_xanthoma": {
                          "description": "Tendon xanthoma in the subject (Nordestgaard 2013 Table 1 physical examination, 6 points). true or false as assigned by the caller. magent does not examine tendons. If corneal_arcus_age_lt_45 is also true, the physical group is 6, not 10.",
                          "type": "boolean"
                        }
                      },
                      "required": [
                        "first_degree_premature_chd",
                        "first_degree_ldl_gt_95th",
                        "first_degree_xanthoma_or_arcus",
                        "child_ldl_gt_95th",
                        "premature_chd",
                        "premature_cerebral_or_pvd",
                        "tendon_xanthoma",
                        "corneal_arcus_age_lt_45",
                        "causative_mutation_ldlr_apob_pcsk9"
                      ],
                      "type": "object"
                    },
                    "maxItems": 25,
                    "minItems": 1,
                    "type": "array"
                  }
                },
                "required": [
                  "items"
                ],
                "type": "object"
              },
              "headers": {
                "additionalProperties": {
                  "type": "string"
                },
                "type": "object"
              },
              "method": {
                "const": "POST",
                "type": "string"
              },
              "type": {
                "const": "http",
                "type": "string"
              }
            },
            "required": [
              "type",
              "method"
            ],
            "type": "object"
          },
          "output": {
            "properties": {
              "example": {
                "type": "object"
              },
              "type": {
                "type": "string"
              }
            },
            "required": [
              "type"
            ],
            "type": "object"
          }
        },
        "required": [
          "input"
        ],
        "type": "object"
      }
    }
  },
  "tags": [
    "dutch-fh",
    "fh",
    "lipids",
    "dlcn",
    "xanthoma",
    "bazaar"
  ],
  "sourceHost": "api.magentlab.com",
  "lastUpdated": "2026-10-12T14:08:28.608Z",
  "quality": {
    "calls30d": 3,
    "uniquePayers30d": 1,
    "lastCalledAt": "2026-10-12T14:08:28.447Z"
  },
  "metadata": {
    "serviceName": "magent",
    "extensions": {
      "bazaar": {
        "info": {
          "iconUrl": "https://api.magentlab.com/favicon.ico",
          "input": {
            "body": {
              "items": [
                {
                  "causative_mutation_ldlr_apob_pcsk9": false,
                  "child_ldl_gt_95th": false,
                  "corneal_arcus_age_lt_45": false,
                  "first_degree_ldl_gt_95th": false,
                  "first_degree_premature_chd": false,
                  "first_degree_xanthoma_or_arcus": false,
                  "ldl_mg_dl": 348,
                  "ldl_mmol_l": 9,
                  "premature_cerebral_or_pvd": false,
                  "premature_chd": false,
                  "tendon_xanthoma": true
                },
                {
                  "causative_mutation_ldlr_apob_pcsk9": false,
                  "child_ldl_gt_95th": false,
                  "corneal_arcus_age_lt_45": false,
                  "first_degree_ldl_gt_95th": false,
                  "first_degree_premature_chd": false,
                  "first_degree_xanthoma_or_arcus": false,
                  "ldl_mg_dl": 348,
                  "ldl_mmol_l": 9,
                  "premature_cerebral_or_pvd": false,
                  "premature_chd": false,
                  "tendon_xanthoma": true
                }
              ]
            },
            "method": "POST",
            "type": "http"
          },
          "output": {
            "example": {
              "count": 2,
              "items": [
                {
                  "citation": {
                    "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
                    "doi": "10.1093/eurheartj/eht273",
                    "id": "nordestgaard-2013",
                    "pmid": "23956253",
                    "source": "Eur Heart J. 2013;34(45):3478-3490",
                    "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
                  },
                  "classification": "definite",
                  "clinical_points": 0,
                  "components": [
                    {
                      "factor": "family",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "clinical",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "physical",
                      "points": 6,
                      "present": true
                    },
                    {
                      "factor": "ldl",
                      "points": 8,
                      "present": true,
                      "value": 9
                    },
                    {
                      "factor": "dna",
                      "points": 0,
                      "present": false
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "dna_points": 0,
                  "family_points": 0,
                  "formula": "dutch_fh",
                  "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
                  "ldl_mmol_l": 9,
                  "ldl_points": 8,
                  "max_score": 26,
                  "physical_points": 6,
                  "score": 14
                },
                {
                  "citation": {
                    "authors": "Nordestgaard BG, Chapman MJ, Humphries SE, et al.",
                    "doi": "10.1093/eurheartj/eht273",
                    "id": "nordestgaard-2013",
                    "pmid": "23956253",
                    "source": "Eur Heart J. 2013;34(45):3478-3490",
                    "title": "Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society"
                  },
                  "classification": "definite",
                  "clinical_points": 0,
                  "components": [
                    {
                      "factor": "family",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "clinical",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "physical",
                      "points": 6,
                      "present": true
                    },
                    {
                      "factor": "ldl",
                      "points": 8,
                      "present": true,
                      "value": 9
                    },
                    {
                      "factor": "dna",
                      "points": 0,
                      "present": false
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "dna_points": 0,
                  "family_points": 0,
                  "formula": "dutch_fh",
                  "formula_expression": "DLCN (Nordestgaard 2013 Table 1) = family + clinical + physical + ldl + dna (per group only the highest); family: first_degree_xanthoma_or_arcus or child_ldl_gt_95th -> 2 else first_degree_premature_chd or first_degree_ldl_gt_95th -> 1; clinical: premature_chd -> 2 else premature_cerebral_or_pvd -> 1; physical: tendon_xanthoma -> 6 else corneal_arcus_age_lt_45 -> 4; ldl mmol/L: >8.5 -> 8, 6.5-8.4 -> 5, 5.0-6.4 -> 3, 4.0-4.9 -> 1; dna causative_mutation_ldlr_apob_pcsk9 -> 8; max 26; definite >8, probable 6-8, possible 3-5, unlikely 0-2",
                  "ldl_mmol_l": 9,
                  "ldl_points": 8,
                  "max_score": 26,
                  "physical_points": 6,
                  "score": 14
                }
              ],
              "path": "/api/calc/dutch_fh"
            },
            "type": "json"
          }
        },
        "schema": {
          "$schema": "https://json-schema.org/draft/2020-12/schema",
          "properties": {
            "input": {
              "additionalProperties": false,
              "properties": {
                "body": {
                  "additionalProperties": false,
                  "properties": {
                    "items": {
                      "items": {
                        "properties": {
                          "causative_mutation_ldlr_apob_pcsk9": {
                            "description": "Causative mutation in LDLR, APOB, or PCSK9 as assigned by the caller (Nordestgaard 2013 Table 1 DNA analysis, 8 points). true or false. magent does not sequence genes. Mutation alone is probable (score 8), not definite.",
                            "type": "boolean"
                          },
                          "child_ldl_gt_95th": {
                            "description": "Child under 18 years with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.",
                            "type": "boolean"
                          },
                          "corneal_arcus_age_lt_45": {
                            "description": "Arcus cornealis before age 45 years (Nordestgaard 2013 Table 1 physical examination, 4 points). true or false as assigned by the caller. magent does not examine the cornea or compute age.",
                            "type": "boolean"
                          },
                          "first_degree_ldl_gt_95th": {
                            "description": "First-degree relative with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not assay lipids or take a pedigree.",
                            "type": "boolean"
                          },
                          "first_degree_premature_chd": {
                            "description": "First-degree relative with premature coronary heart disease (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not take a pedigree. Either this or first_degree_ldl_gt_95th scores 1 for the family group; a 2-point family item still yields family 2, not 3.",
                            "type": "boolean"
                          },
                          "first_degree_xanthoma_or_arcus": {
                            "description": "First-degree relative with tendon xanthoma and/or arcus cornealis (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not examine relatives. Either this or child_ldl_gt_95th scores 2 for the family group (max of family items).",
                            "type": "boolean"
                          },
                          "ldl_mg_dl": {
                            "description": "LDL cholesterol in mg/dL (40-800). Converted to mmol/L as mg/dL / 38.67, then scored on the mmol/L bands. Provide exactly one lipid parameter.",
                            "type": "number"
                          },
                          "ldl_mmol_l": {
                            "description": "LDL cholesterol in mmol/L (1-20). Nordestgaard 2013 Table 1 bands: >8.5 → 8, 6.5-8.4 → 5, 5.0-6.4 → 3, 4.0-4.9 → 1. Provide exactly one of ldl_mmol_l or ldl_mg_dl. magent does not assay lipids.",
                            "type": "number"
                          },
                          "premature_cerebral_or_pvd": {
                            "description": "Premature cerebral or peripheral vascular disease in the subject (Nordestgaard 2013 Table 1 clinical history, 1 point). true or false as assigned by the caller. magent does not diagnose vascular disease.",
                            "type": "boolean"
                          },
                          "premature_chd": {
                            "description": "Premature coronary heart disease in the subject (Nordestgaard 2013 Table 1 clinical history, 2 points; men <55 years / women <60 years as assigned by the caller). true or false. magent does not diagnose CHD or compute age or sex. If premature_cerebral_or_pvd is also true, the clinical group is 2, not 3.",
                            "type": "boolean"
                          },
                          "tendon_xanthoma": {
                            "description": "Tendon xanthoma in the subject (Nordestgaard 2013 Table 1 physical examination, 6 points). true or false as assigned by the caller. magent does not examine tendons. If corneal_arcus_age_lt_45 is also true, the physical group is 6, not 10.",
                            "type": "boolean"
                          }
                        },
                        "required": [
                          "first_degree_premature_chd",
                          "first_degree_ldl_gt_95th",
                          "first_degree_xanthoma_or_arcus",
                          "child_ldl_gt_95th",
                          "premature_chd",
                          "premature_cerebral_or_pvd",
                          "tendon_xanthoma",
                          "corneal_arcus_age_lt_45",
                          "causative_mutation_ldlr_apob_pcsk9"
                        ],
                        "type": "object"
                      },
                      "maxItems": 25,
                      "minItems": 1,
                      "type": "array"
                    }
                  },
                  "required": [
                    "items"
                  ],
                  "type": "object"
                },
                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
              ],
              "type": "object"
            },
            "output": {
              "properties": {
                "example": {
                  "type": "object"
                },
                "type": {
                  "type": "string"
                }
              },
              "required": [
                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
  }
}