{ "x402Version": 2, "id": 39587, "slug": "39587", "resource": "https://api.magentlab.com/api/calc/hfa_icos_myeloma", "description": "Lyon 2020 HFA-ICOS baseline CV risk before proteasome inhibitors and immunomodulatory drugs for multiple myeloma. Returns risk_level low, medium, high, or very_high plus medium_points and the paper's expert-opinion cardiotoxicity_guide. Age >=75 is High; 65-74 is Medium 1. Caller assigns labs, BMI >30, and high-dose dexamethasone. magent does not examine the patient or read imaging. Not a medical device or treatment order.", "type": "http", "serviceName": "magent", "resourceType": "Agent Service", "accepts": [ { "scheme": "exact", "network": "eip155:8453", "payTo": "0x836Be278f1739fB4308091cD1852F7971Bc19Ee2", "asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913", "amount": "5000", "amountUsd": 0.005, "maxTimeoutSeconds": 600 } ], "outputSchema": { "properties": { "example": { "type": "object" }, "type": { "type": "string" } }, "required": [ "type" ], "type": "object" }, "extensions": { "bazaar": { "info": { "iconUrl": "https://api.magentlab.com/favicon.ico", "input": { "body": { "items": [ { "age_years": 50, "arrhythmia": false, "arterial_vascular_disease": false, "cardiac_amyloidosis": false, "ckd": false, "current_or_significant_smoker": false, "diabetes": false, "elevated_bnp": false, "elevated_troponin": false, "family_history_thrombophilia": false, "heart_failure_or_cardiomyopathy": false, "high_dose_dexamethasone": false, "hyperlipidemia": false, "hypertension": false, "left_ventricular_hypertrophy": false, "lvef_percent": 60, "obesity": false, "prior_anthracycline": false, "prior_immunomodulatory_drug_cv_toxicity": false, "prior_proteasome_inhibitor_cardiotoxicity": false, "prior_thoracic_spine_radiotherapy": false, "venous_thrombosis": false }, { "age_years": 50, "arrhythmia": false, "arterial_vascular_disease": false, "cardiac_amyloidosis": false, "ckd": false, "current_or_significant_smoker": false, "diabetes": false, "elevated_bnp": false, "elevated_troponin": false, "family_history_thrombophilia": false, "heart_failure_or_cardiomyopathy": false, "high_dose_dexamethasone": false, "hyperlipidemia": false, "hypertension": false, "left_ventricular_hypertrophy": false, "lvef_percent": 60, "obesity": false, "prior_anthracycline": false, "prior_immunomodulatory_drug_cv_toxicity": false, "prior_proteasome_inhibitor_cardiotoxicity": false, "prior_thoracic_spine_radiotherapy": false, "venous_thrombosis": false } ] }, "method": "POST", "type": "http" }, "output": { "example": { "count": 2, "items": [ { "age_years": 50, "cardiotoxicity_guide": "<2%", "citation": { "authors": "Lyon AR, Dent S, Stanway S, et al.", "doi": "10.1002/ejhf.1920", "id": "lyon-2020", "pmid": "32458582", "source": "Eur J Heart Fail. 2020;22(11):1945-1960", "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society" }, "components": [ { "factor": "heart_failure_or_cardiomyopathy", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_proteasome_inhibitor_cardiotoxicity", "points": 0, "present": false, "tier": "very_high" }, { "factor": "venous_thrombosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "cardiac_amyloidosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "arterial_vascular_disease", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_immunomodulatory_drug_cv_toxicity", "points": 0, "present": false, "tier": "high" }, { "factor": "elevated_bnp", "points": 0, "present": false, "tier": "high" }, { "factor": "prior_anthracycline", "points": 0, "present": false, "tier": "high" }, { "factor": "arrhythmia", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "elevated_troponin", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "left_ventricular_hypertrophy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hypertension", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "diabetes", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hyperlipidemia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "ckd", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "family_history_thrombophilia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "prior_thoracic_spine_radiotherapy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "high_dose_dexamethasone", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "current_or_significant_smoker", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "obesity", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "age_years", "points": 0, "present": false, "tier": "none", "value": 50 }, { "factor": "lvef_percent", "points": 0, "present": false, "tier": "none", "value": 60 } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "formula": "hfa_icos_myeloma", "formula_expression": "very_high if any Very high factor (heart_failure_or_cardiomyopathy, prior_proteasome_inhibitor_cardiotoxicity, venous_thrombosis, cardiac_amyloidosis, arterial_vascular_disease); else high if any High factor (prior_immunomodulatory_drug_cv_toxicity, lvef_percent<50, elevated_bnp, age_years>=75, prior_anthracycline) OR medium_points>=5; else medium if medium_points in 2..4; else low (no factors or one Medium 1). medium_points sums Medium 1 (=1: left_ventricular_hypertrophy, age_years 65-74, hypertension, diabetes, hyperlipidemia, ckd, family_history_thrombophilia, prior_thoracic_spine_radiotherapy, high_dose_dexamethasone, current_or_significant_smoker, obesity) and Medium 2 (=2: lvef_percent 50-54, arrhythmia, elevated_troponin) only. Age and LVEF use the highest matching printed band. Lyon 2020 HFA-ICOS multiple-myeloma therapy table. cardiotoxicity_guide is that paper's expert-opinion guide: low <2%, medium 2-9%, high 10-19%, very high >=20%", "lvef_percent": 60, "medium_points": 0, "risk_level": "low" }, { "age_years": 50, "cardiotoxicity_guide": "<2%", "citation": { "authors": "Lyon AR, Dent S, Stanway S, et al.", "doi": "10.1002/ejhf.1920", "id": "lyon-2020", "pmid": "32458582", "source": "Eur J Heart Fail. 2020;22(11):1945-1960", "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society" }, "components": [ { "factor": "heart_failure_or_cardiomyopathy", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_proteasome_inhibitor_cardiotoxicity", "points": 0, "present": false, "tier": "very_high" }, { "factor": "venous_thrombosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "cardiac_amyloidosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "arterial_vascular_disease", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_immunomodulatory_drug_cv_toxicity", "points": 0, "present": false, "tier": "high" }, { "factor": "elevated_bnp", "points": 0, "present": false, "tier": "high" }, { "factor": "prior_anthracycline", "points": 0, "present": false, "tier": "high" }, { "factor": "arrhythmia", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "elevated_troponin", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "left_ventricular_hypertrophy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hypertension", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "diabetes", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hyperlipidemia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "ckd", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "family_history_thrombophilia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "prior_thoracic_spine_radiotherapy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "high_dose_dexamethasone", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "current_or_significant_smoker", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "obesity", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "age_years", "points": 0, "present": false, "tier": "none", "value": 50 }, { "factor": "lvef_percent", "points": 0, "present": false, "tier": "none", "value": 60 } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "formula": "hfa_icos_myeloma", "formula_expression": "very_high if any Very high factor (heart_failure_or_cardiomyopathy, prior_proteasome_inhibitor_cardiotoxicity, venous_thrombosis, cardiac_amyloidosis, arterial_vascular_disease); else high if any High factor (prior_immunomodulatory_drug_cv_toxicity, lvef_percent<50, elevated_bnp, age_years>=75, prior_anthracycline) OR medium_points>=5; else medium if medium_points in 2..4; else low (no factors or one Medium 1). medium_points sums Medium 1 (=1: left_ventricular_hypertrophy, age_years 65-74, hypertension, diabetes, hyperlipidemia, ckd, family_history_thrombophilia, prior_thoracic_spine_radiotherapy, high_dose_dexamethasone, current_or_significant_smoker, obesity) and Medium 2 (=2: lvef_percent 50-54, arrhythmia, elevated_troponin) only. Age and LVEF use the highest matching printed band. Lyon 2020 HFA-ICOS multiple-myeloma therapy table. cardiotoxicity_guide is that paper's expert-opinion guide: low <2%, medium 2-9%, high 10-19%, very high >=20%", "lvef_percent": 60, "medium_points": 0, "risk_level": "low" } ], "path": "/api/calc/hfa_icos_myeloma" }, "type": "json" } }, "schema": { "$schema": "https://json-schema.org/draft/2020-12/schema", "properties": { "input": { "additionalProperties": false, "properties": { "body": { "additionalProperties": false, "properties": { "items": { "items": { "properties": { "age_years": { "description": "Age in years (18-100, integer). Lyon 2020 myeloma-therapy table: >=75 High; 65-74 Medium 1; <65 no age factor. Highest matching band only.", "type": "integer" }, "arrhythmia": { "description": "Arrhythmia (Lyon 2020 Medium 2). true or false as assigned by the caller. magent does not read a rhythm strip.", "type": "boolean" }, "arterial_vascular_disease": { "description": "Arterial vascular disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD) as one caller bool (Lyon 2020 Very high). true or false. magent does not diagnose vascular disease.", "type": "boolean" }, "cardiac_amyloidosis": { "description": "Cardiac amyloidosis (Lyon 2020 Very high). true or false as assigned by the caller. magent does not read imaging or biopsy.", "type": "boolean" }, "ckd": { "description": "Chronic kidney disease as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not compute eGFR.", "type": "boolean" }, "current_or_significant_smoker": { "description": "Current smoker or significant smoking history (Lyon 2020 Medium 1). true or false as assigned by the caller.", "type": "boolean" }, "diabetes": { "description": "Diabetes mellitus as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not assay HbA1c.", "type": "boolean" }, "elevated_bnp": { "description": "Baseline BNP or NT-proBNP above the local laboratory ULN as assigned by the caller (Lyon 2020 High). true or false. magent does not assay natriuretic peptides.", "type": "boolean" }, "elevated_troponin": { "description": "Baseline troponin above the local laboratory ULN as assigned by the caller (Lyon 2020 Medium 2). true or false. magent does not assay troponin.", "type": "boolean" }, "family_history_thrombophilia": { "description": "Family history of thrombophilia (Lyon 2020 Medium 1). true or false as assigned by the caller. magent does not take a family history.", "type": "boolean" }, "heart_failure_or_cardiomyopathy": { "description": "Heart failure or cardiomyopathy (Lyon 2020 Very high). true or false as assigned by the caller. magent does not examine the patient or read imaging.", "type": "boolean" }, "high_dose_dexamethasone": { "description": "High-dose dexamethasone (>160 mg/month) as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not compute a steroid dose.", "type": "boolean" }, "hyperlipidemia": { "description": "Hyperlipidemia as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not assay lipids.", "type": "boolean" }, "hypertension": { "description": "Hypertension as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not measure blood pressure.", "type": "boolean" }, "left_ventricular_hypertrophy": { "description": "Left-ventricular hypertrophy (Lyon 2020 Medium 1). true or false as assigned by the caller. magent does not read imaging.", "type": "boolean" }, "lvef_percent": { "description": "LVEF percent (10-80, integer). Lyon 2020: <50 High; 50-54 Medium 2; >=55 no LVEF factor. Highest matching printed band only. magent does not read imaging.", "type": "integer" }, "obesity": { "description": "Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not compute BMI.", "type": "boolean" }, "prior_anthracycline": { "description": "Prior anthracycline exposure (Lyon 2020 High). true or false as assigned by the caller.", "type": "boolean" }, "prior_immunomodulatory_drug_cv_toxicity": { "description": "Prior immunomodulatory-drug cardiovascular toxicity (Lyon 2020 High). true or false as assigned by the caller.", "type": "boolean" }, "prior_proteasome_inhibitor_cardiotoxicity": { "description": "Prior proteasome-inhibitor cardiotoxicity (Lyon 2020 Very high). true or false as assigned by the caller.", "type": "boolean" }, "prior_thoracic_spine_radiotherapy": { "description": "Prior thoracic-spine radiotherapy (Lyon 2020 Medium 1). true or false as assigned by the caller.", "type": "boolean" }, "venous_thrombosis": { "description": "Venous thrombosis (DVT or PE) (Lyon 2020 Very high). true or false as assigned by the caller. magent does not diagnose thrombosis.", "type": "boolean" } }, "required": [ "age_years", "lvef_percent", "heart_failure_or_cardiomyopathy", "prior_proteasome_inhibitor_cardiotoxicity", "venous_thrombosis", "cardiac_amyloidosis", "arterial_vascular_disease", "prior_immunomodulatory_drug_cv_toxicity", "elevated_bnp", "prior_anthracycline", "arrhythmia", "elevated_troponin", "left_ventricular_hypertrophy", "hypertension", "diabetes", "hyperlipidemia", "ckd", "family_history_thrombophilia", "prior_thoracic_spine_radiotherapy", "high_dose_dexamethasone", "current_or_significant_smoker", "obesity" ], "type": "object" }, "maxItems": 25, "minItems": 1, "type": "array" } }, "required": [ "items" ], "type": "object" }, "headers": { "additionalProperties": { "type": "string" }, "type": "object" }, "method": { "const": "POST", "type": "string" }, "type": { "const": "http", "type": "string" } }, "required": [ "type", "method" ], "type": "object" }, "output": { "properties": { "example": { "type": "object" }, "type": { "type": "string" } }, "required": [ "type" ], "type": "object" } }, "required": [ "input" ], "type": "object" } } }, "tags": [ "hfa-icos", "myeloma", "cardio-oncology", "hemodynamics", "calculator", "bazaar" ], "sourceHost": "api.magentlab.com", "lastUpdated": "2026-10-12T13:35:45.393Z", "quality": { "calls30d": 3, "uniquePayers30d": 1, "lastCalledAt": "2026-10-12T13:35:45.235Z" }, "metadata": { "serviceName": "magent", "extensions": { "bazaar": { "info": { "iconUrl": "https://api.magentlab.com/favicon.ico", "input": { "body": { "items": [ { "age_years": 50, "arrhythmia": false, "arterial_vascular_disease": false, "cardiac_amyloidosis": false, "ckd": false, "current_or_significant_smoker": false, "diabetes": false, "elevated_bnp": false, "elevated_troponin": false, "family_history_thrombophilia": false, "heart_failure_or_cardiomyopathy": false, "high_dose_dexamethasone": false, "hyperlipidemia": false, "hypertension": false, "left_ventricular_hypertrophy": false, "lvef_percent": 60, "obesity": false, "prior_anthracycline": false, "prior_immunomodulatory_drug_cv_toxicity": false, "prior_proteasome_inhibitor_cardiotoxicity": false, "prior_thoracic_spine_radiotherapy": false, "venous_thrombosis": false }, { "age_years": 50, "arrhythmia": false, "arterial_vascular_disease": false, "cardiac_amyloidosis": false, "ckd": false, "current_or_significant_smoker": false, "diabetes": false, "elevated_bnp": false, "elevated_troponin": false, "family_history_thrombophilia": false, "heart_failure_or_cardiomyopathy": false, "high_dose_dexamethasone": false, "hyperlipidemia": false, "hypertension": false, "left_ventricular_hypertrophy": false, "lvef_percent": 60, "obesity": false, "prior_anthracycline": false, "prior_immunomodulatory_drug_cv_toxicity": false, "prior_proteasome_inhibitor_cardiotoxicity": false, "prior_thoracic_spine_radiotherapy": false, "venous_thrombosis": false } ] }, "method": "POST", "type": "http" }, "output": { "example": { "count": 2, "items": [ { "age_years": 50, "cardiotoxicity_guide": "<2%", "citation": { "authors": "Lyon AR, Dent S, Stanway S, et al.", "doi": "10.1002/ejhf.1920", "id": "lyon-2020", "pmid": "32458582", "source": "Eur J Heart Fail. 2020;22(11):1945-1960", "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society" }, "components": [ { "factor": "heart_failure_or_cardiomyopathy", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_proteasome_inhibitor_cardiotoxicity", "points": 0, "present": false, "tier": "very_high" }, { "factor": "venous_thrombosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "cardiac_amyloidosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "arterial_vascular_disease", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_immunomodulatory_drug_cv_toxicity", "points": 0, "present": false, "tier": "high" }, { "factor": "elevated_bnp", "points": 0, "present": false, "tier": "high" }, { "factor": "prior_anthracycline", "points": 0, "present": false, "tier": "high" }, { "factor": "arrhythmia", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "elevated_troponin", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "left_ventricular_hypertrophy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hypertension", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "diabetes", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hyperlipidemia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "ckd", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "family_history_thrombophilia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "prior_thoracic_spine_radiotherapy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "high_dose_dexamethasone", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "current_or_significant_smoker", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "obesity", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "age_years", "points": 0, "present": false, "tier": "none", "value": 50 }, { "factor": "lvef_percent", "points": 0, "present": false, "tier": "none", "value": 60 } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "formula": "hfa_icos_myeloma", "formula_expression": "very_high if any Very high factor (heart_failure_or_cardiomyopathy, prior_proteasome_inhibitor_cardiotoxicity, venous_thrombosis, cardiac_amyloidosis, arterial_vascular_disease); else high if any High factor (prior_immunomodulatory_drug_cv_toxicity, lvef_percent<50, elevated_bnp, age_years>=75, prior_anthracycline) OR medium_points>=5; else medium if medium_points in 2..4; else low (no factors or one Medium 1). medium_points sums Medium 1 (=1: left_ventricular_hypertrophy, age_years 65-74, hypertension, diabetes, hyperlipidemia, ckd, family_history_thrombophilia, prior_thoracic_spine_radiotherapy, high_dose_dexamethasone, current_or_significant_smoker, obesity) and Medium 2 (=2: lvef_percent 50-54, arrhythmia, elevated_troponin) only. Age and LVEF use the highest matching printed band. Lyon 2020 HFA-ICOS multiple-myeloma therapy table. cardiotoxicity_guide is that paper's expert-opinion guide: low <2%, medium 2-9%, high 10-19%, very high >=20%", "lvef_percent": 60, "medium_points": 0, "risk_level": "low" }, { "age_years": 50, "cardiotoxicity_guide": "<2%", "citation": { "authors": "Lyon AR, Dent S, Stanway S, et al.", "doi": "10.1002/ejhf.1920", "id": "lyon-2020", "pmid": "32458582", "source": "Eur J Heart Fail. 2020;22(11):1945-1960", "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society" }, "components": [ { "factor": "heart_failure_or_cardiomyopathy", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_proteasome_inhibitor_cardiotoxicity", "points": 0, "present": false, "tier": "very_high" }, { "factor": "venous_thrombosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "cardiac_amyloidosis", "points": 0, "present": false, "tier": "very_high" }, { "factor": "arterial_vascular_disease", "points": 0, "present": false, "tier": "very_high" }, { "factor": "prior_immunomodulatory_drug_cv_toxicity", "points": 0, "present": false, "tier": "high" }, { "factor": "elevated_bnp", "points": 0, "present": false, "tier": "high" }, { "factor": "prior_anthracycline", "points": 0, "present": false, "tier": "high" }, { "factor": "arrhythmia", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "elevated_troponin", "points": 0, "present": false, "tier": "medium_2" }, { "factor": "left_ventricular_hypertrophy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hypertension", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "diabetes", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "hyperlipidemia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "ckd", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "family_history_thrombophilia", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "prior_thoracic_spine_radiotherapy", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "high_dose_dexamethasone", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "current_or_significant_smoker", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "obesity", "points": 0, "present": false, "tier": "medium_1" }, { "factor": "age_years", "points": 0, "present": false, "tier": "none", "value": 50 }, { "factor": "lvef_percent", "points": 0, "present": false, "tier": "none", "value": 60 } ], "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.", "formula": "hfa_icos_myeloma", "formula_expression": "very_high if any Very high factor (heart_failure_or_cardiomyopathy, prior_proteasome_inhibitor_cardiotoxicity, venous_thrombosis, cardiac_amyloidosis, arterial_vascular_disease); else high if any High factor (prior_immunomodulatory_drug_cv_toxicity, lvef_percent<50, elevated_bnp, age_years>=75, prior_anthracycline) OR medium_points>=5; else medium if medium_points in 2..4; else low (no factors or one Medium 1). medium_points sums Medium 1 (=1: left_ventricular_hypertrophy, age_years 65-74, hypertension, diabetes, hyperlipidemia, ckd, family_history_thrombophilia, prior_thoracic_spine_radiotherapy, high_dose_dexamethasone, current_or_significant_smoker, obesity) and Medium 2 (=2: lvef_percent 50-54, arrhythmia, elevated_troponin) only. Age and LVEF use the highest matching printed band. Lyon 2020 HFA-ICOS multiple-myeloma therapy table. cardiotoxicity_guide is that paper's expert-opinion guide: low <2%, medium 2-9%, high 10-19%, very high >=20%", "lvef_percent": 60, "medium_points": 0, "risk_level": "low" } ], "path": "/api/calc/hfa_icos_myeloma" }, "type": "json" } }, "schema": { "$schema": "https://json-schema.org/draft/2020-12/schema", "properties": { "input": { "additionalProperties": false, "properties": { "body": { "additionalProperties": false, "properties": { "items": { "items": { "properties": { "age_years": { "description": "Age in years (18-100, integer). Lyon 2020 myeloma-therapy table: >=75 High; 65-74 Medium 1; <65 no age factor. Highest matching band only.", "type": "integer" }, "arrhythmia": { "description": "Arrhythmia (Lyon 2020 Medium 2). true or false as assigned by the caller. magent does not read a rhythm strip.", "type": "boolean" }, "arterial_vascular_disease": { "description": "Arterial vascular disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD) as one caller bool (Lyon 2020 Very high). true or false. magent does not diagnose vascular disease.", "type": "boolean" }, "cardiac_amyloidosis": { "description": "Cardiac amyloidosis (Lyon 2020 Very high). true or false as assigned by the caller. magent does not read imaging or biopsy.", "type": "boolean" }, "ckd": { "description": "Chronic kidney disease as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not compute eGFR.", "type": "boolean" }, "current_or_significant_smoker": { "description": "Current smoker or significant smoking history (Lyon 2020 Medium 1). true or false as assigned by the caller.", "type": "boolean" }, "diabetes": { "description": "Diabetes mellitus as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not assay HbA1c.", "type": "boolean" }, "elevated_bnp": { "description": "Baseline BNP or NT-proBNP above the local laboratory ULN as assigned by the caller (Lyon 2020 High). true or false. magent does not assay natriuretic peptides.", "type": "boolean" }, "elevated_troponin": { "description": "Baseline troponin above the local laboratory ULN as assigned by the caller (Lyon 2020 Medium 2). true or false. magent does not assay troponin.", "type": "boolean" }, "family_history_thrombophilia": { "description": "Family history of thrombophilia (Lyon 2020 Medium 1). true or false as assigned by the caller. magent does not take a family history.", "type": "boolean" }, "heart_failure_or_cardiomyopathy": { "description": "Heart failure or cardiomyopathy (Lyon 2020 Very high). true or false as assigned by the caller. magent does not examine the patient or read imaging.", "type": "boolean" }, "high_dose_dexamethasone": { "description": "High-dose dexamethasone (>160 mg/month) as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not compute a steroid dose.", "type": "boolean" }, "hyperlipidemia": { "description": "Hyperlipidemia as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not assay lipids.", "type": "boolean" }, "hypertension": { "description": "Hypertension as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not measure blood pressure.", "type": "boolean" }, "left_ventricular_hypertrophy": { "description": "Left-ventricular hypertrophy (Lyon 2020 Medium 1). true or false as assigned by the caller. magent does not read imaging.", "type": "boolean" }, "lvef_percent": { "description": "LVEF percent (10-80, integer). Lyon 2020: <50 High; 50-54 Medium 2; >=55 no LVEF factor. Highest matching printed band only. magent does not read imaging.", "type": "integer" }, "obesity": { "description": "Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 Medium 1). true or false. magent does not compute BMI.", "type": "boolean" }, "prior_anthracycline": { "description": "Prior anthracycline exposure (Lyon 2020 High). true or false as assigned by the caller.", "type": "boolean" }, "prior_immunomodulatory_drug_cv_toxicity": { "description": "Prior immunomodulatory-drug cardiovascular toxicity (Lyon 2020 High). true or false as assigned by the caller.", "type": "boolean" }, "prior_proteasome_inhibitor_cardiotoxicity": { "description": "Prior proteasome-inhibitor cardiotoxicity (Lyon 2020 Very high). true or false as assigned by the caller.", "type": "boolean" }, "prior_thoracic_spine_radiotherapy": { "description": "Prior thoracic-spine radiotherapy (Lyon 2020 Medium 1). true or false as assigned by the caller.", "type": "boolean" }, "venous_thrombosis": { "description": "Venous thrombosis (DVT or PE) (Lyon 2020 Very high). true or false as assigned by the caller. magent does not diagnose thrombosis.", "type": "boolean" } }, "required": [ "age_years", "lvef_percent", "heart_failure_or_cardiomyopathy", "prior_proteasome_inhibitor_cardiotoxicity", "venous_thrombosis", "cardiac_amyloidosis", "arterial_vascular_disease", "prior_immunomodulatory_drug_cv_toxicity", "elevated_bnp", "prior_anthracycline", "arrhythmia", "elevated_troponin", "left_ventricular_hypertrophy", "hypertension", "diabetes", "hyperlipidemia", "ckd", "family_history_thrombophilia", "prior_thoracic_spine_radiotherapy", "high_dose_dexamethasone", "current_or_significant_smoker", "obesity" ], "type": "object" }, "maxItems": 25, "minItems": 1, "type": "array" } }, "required": [ "items" ], "type": "object" }, "headers": { "additionalProperties": { "type": "string" }, "type": "object" }, "method": { "const": "POST", "type": "string" }, "type": { "const": "http", "type": "string" } }, "required": [ "type", "method" ], "type": "object" }, "output": { "properties": { "example": { "type": "object" }, "type": { "type": "string" } }, "required": [ "type" ], "type": "object" } }, "required": [ "input" ], "type": "object" } } } }, "liveness": { "reliability": null }, "verified": false, "featured": false, "provider": { "host": "api.magentlab.com", "manifest_name": "api.magentlab.com", "source": "cdp-mirror", "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources", "submitted_at": "2026-10-14T01:15:01.050Z" }, "exampleResponse": { "example": {}, "type": "string" } }