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                  "formula_expression": "HFA-ICOS BCR-ABL TKI (Lyon 2020) = very_high if arterial_vascular_disease or arterial_thrombosis_with_tki; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low (0 or one M1); medium_points = M2*2 + M1*1 only; High: heart_failure_or_lvsd, bcr_abl_tki_mediated_lvsd, abpi_le_0_9, pulmonary_arterial_hypertension, LVEF<50, QTc>=480, caller cvd_10y_risk_gt_20, age>=75, current_or_significant_smoker; M2: venous_thromboembolism, arrhythmia, borderline QTc (men 450<=QTc<480, women 460<=QTc<480), hypertension, age 65-74; M1: diabetes, hyperlipidemia, age 60-64, ckd, family_history_thrombophilia, obesity; age bands mutually exclusive; no LVEF 50-54 row; magent does not compute 10-year CVD risk",
                  "lvef_percent": 60,
                  "medium_points": 0,
                  "qtc_ms": 400,
                  "risk_level": "low",
                  "sex": "female"
                },
                {
                  "age_years": 50,
                  "cardiotoxicity_guide": "<2%",
                  "citation": {
                    "authors": "Lyon AR, Dent S, Stanway S, et al.",
                    "doi": "10.1002/ejhf.1920",
                    "id": "lyon-2020",
                    "pmid": "32458582",
                    "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
                    "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
                  },
                  "components": [
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                      "factor": "arterial_vascular_disease",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "arterial_thrombosis_with_tki",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "heart_failure_or_lvsd",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "bcr_abl_tki_mediated_lvsd",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "abpi_le_0_9",
                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "pulmonary_arterial_hypertension",
                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "cvd_10y_risk_gt_20",
                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "venous_thromboembolism",
                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
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                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
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                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "hyperlipidemia",
                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
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                      "points": 0,
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                    },
                    {
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                      "points": 0,
                      "present": false
                    },
                    {
                      "factor": "obesity",
                      "points": 0,
                      "present": false
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "hfa_icos_bcr_abl",
                  "formula_expression": "HFA-ICOS BCR-ABL TKI (Lyon 2020) = very_high if arterial_vascular_disease or arterial_thrombosis_with_tki; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low (0 or one M1); medium_points = M2*2 + M1*1 only; High: heart_failure_or_lvsd, bcr_abl_tki_mediated_lvsd, abpi_le_0_9, pulmonary_arterial_hypertension, LVEF<50, QTc>=480, caller cvd_10y_risk_gt_20, age>=75, current_or_significant_smoker; M2: venous_thromboembolism, arrhythmia, borderline QTc (men 450<=QTc<480, women 460<=QTc<480), hypertension, age 65-74; M1: diabetes, hyperlipidemia, age 60-64, ckd, family_history_thrombophilia, obesity; age bands mutually exclusive; no LVEF 50-54 row; magent does not compute 10-year CVD risk",
                  "lvef_percent": 60,
                  "medium_points": 0,
                  "qtc_ms": 400,
                  "risk_level": "low",
                  "sex": "female"
                }
              ],
              "path": "/api/calc/hfa_icos_bcr_abl"
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          }
        },
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                            "description": "Caller-assigned abnormal ankle-brachial pressure index (paper: ABPI ≤0.9). High. magent does not measure ABPI.",
                            "type": "boolean"
                          },
                          "age_years": {
                            "description": "Age in years (integer 18-100). Lyon 2020 BCR-ABL table: ≥75 High; 65-74 Medium 2; 60-64 Medium 1 (paper row Age ≥60 years under the higher bands); <60 none. Bands do not stack. magent does not examine the patient.",
                            "type": "integer"
                          },
                          "arrhythmia": {
                            "description": "Caller-assigned arrhythmia (paper: atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation). Medium 2. magent does not read a rhythm strip.",
                            "type": "boolean"
                          },
                          "arterial_thrombosis_with_tki": {
                            "description": "Caller-assigned arterial thrombosis associated with a BCR-ABL TKI. Very high. magent does not diagnose thrombosis.",
                            "type": "boolean"
                          },
                          "arterial_vascular_disease": {
                            "description": "Caller-assigned arterial vascular disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). Very high. magent does not diagnose vascular disease.",
                            "type": "boolean"
                          },
                          "bcr_abl_tki_mediated_lvsd": {
                            "description": "Caller-assigned BCR-ABL TKI-mediated LVSD. High. magent does not attribute LVSD to a TKI.",
                            "type": "boolean"
                          },
                          "ckd": {
                            "description": "Caller-assigned chronic kidney disease (paper: eGFR <60 mL/min/1.73 m²). Medium 1. magent does not compute eGFR.",
                            "type": "boolean"
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                          "current_or_significant_smoker": {
                            "description": "Caller-assigned current smoker or significant smoking history. High on this BCR-ABL table (not Medium 1). magent does not take a smoking history.",
                            "type": "boolean"
                          },
                          "cvd_10y_risk_gt_20": {
                            "description": "Caller-assigned paper row Cardiovascular disease 10-year risk score >20%. High. magent does not compute SCORE2, PCE, or any other 10-year CVD equation.",
                            "type": "boolean"
                          },
                          "diabetes": {
                            "description": "Caller-assigned diabetes (paper: HbA1c >7.0% or >53 mmol/mol, or on treatment). Medium 1. magent does not diagnose diabetes.",
                            "type": "boolean"
                          },
                          "family_history_thrombophilia": {
                            "description": "Caller-assigned family history of thrombophilia. Medium 1. magent does not take a family history.",
                            "type": "boolean"
                          },
                          "heart_failure_or_lvsd": {
                            "description": "Caller-assigned heart failure or left-ventricular systolic dysfunction. High. magent does not diagnose heart failure.",
                            "type": "boolean"
                          },
                          "hyperlipidemia": {
                            "description": "Caller-assigned hyperlipidemia (paper: non-HDL cholesterol >3.8 mmol/L or >145 mg/dL). Medium 1. magent does not assay lipids.",
                            "type": "boolean"
                          },
                          "hypertension": {
                            "description": "Caller-assigned hypertension (paper: SBP >140 mmHg or DBP >90 mmHg, or on treatment). Medium 2. magent does not measure blood pressure.",
                            "type": "boolean"
                          },
                          "lvef_percent": {
                            "description": "Left-ventricular ejection fraction in percent (10-80). <50 is High. This table has no 50-54 Medium 2 LVEF row; ≥50 adds no LVEF points. magent does not read an echocardiogram.",
                            "type": "number"
                          },
                          "obesity": {
                            "description": "Caller-assigned obesity (paper: BMI >30 kg/m²). Medium 1. magent does not compute BMI.",
                            "type": "boolean"
                          },
                          "pulmonary_arterial_hypertension": {
                            "description": "Caller-assigned pulmonary arterial hypertension (paper: peak systolic PAP ≥35 mmHg when estimated on echocardiography). High. magent does not estimate pulmonary pressure.",
                            "type": "boolean"
                          },
                          "qtc_ms": {
                            "description": "QTc in milliseconds (300-700). ≥480 is High. Borderline Medium 2 is men 450≤QTc<480 and women 460≤QTc<480. magent does not measure QTc.",
                            "type": "number"
                          },
                          "sex": {
                            "description": "Sex male or female. Selects the borderline QTc Medium 2 window (men 450≤QTc<480; women 460≤QTc<480). magent does not read an ECG.",
                            "type": "string"
                          },
                          "venous_thromboembolism": {
                            "description": "Caller-assigned venous thromboembolism (DVT or PE). Medium 2. magent does not diagnose VTE.",
                            "type": "boolean"
                          }
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                          "diabetes",
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  "liveness": {
    "reliability": null
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  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
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