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                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "proteinuria",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "prior_left_chest_or_mediastinal_rt",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "current_or_significant_smoker",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "obesity",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "hfa_icos_vegf",
                  "formula_expression": "HFA-ICOS VEGF-inhibitor class (Lyon 2020): very_high if any very-high factor; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low. medium_points = Medium 2 + Medium 1 only. Very high: heart_failure_or_cardiomyopathy, arterial_vascular_disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). High: venous_thrombosis, lvef_percent<50, qtc_ms>=480, age_years>=75, hypertension, prior_anthracycline. Medium 2: lvef 50-54, male 450<=qtc<480, female 460<=qtc<480, arrhythmia (AF/flutter/VT/VF). Medium 1: elevated_troponin, elevated_bnp, age 65-74, diabetes, hyperlipidemia, ckd, proteinuria, prior_left_chest_or_mediastinal_rt, current_or_significant_smoker, obesity. Age exclusive (>=75 High; 65-74 Medium 1; <65 none). LVEF exclusive (<50 High; 50-54 Medium 2; >=55 none). QTc exclusive (>=480 High; else sex-specific Medium 2). cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
                  "high_factor": false,
                  "lvef_percent": 60,
                  "medium_points": 0,
                  "qtc_ms": 400,
                  "risk_level": "low",
                  "sex": "female",
                  "very_high_factor": false
                },
                {
                  "age_years": 50,
                  "cardiotoxicity_guide": "<2%",
                  "citation": {
                    "authors": "Lyon AR, Dent S, Stanway S, et al.",
                    "doi": "10.1002/ejhf.1920",
                    "id": "lyon-2020",
                    "pmid": "32458582",
                    "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
                    "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
                  },
                  "components": [
                    {
                      "factor": "heart_failure_or_cardiomyopathy",
                      "points": 0,
                      "present": false,
                      "tier": "very_high"
                    },
                    {
                      "factor": "arterial_vascular_disease",
                      "points": 0,
                      "present": false,
                      "tier": "very_high"
                    },
                    {
                      "factor": "venous_thrombosis",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "lvef_lt_50",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "qtc_ge_480",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "age_ge_75",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "hypertension",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "prior_anthracycline",
                      "points": 0,
                      "present": false,
                      "tier": "high"
                    },
                    {
                      "factor": "lvef_50_to_54",
                      "points": 0,
                      "present": false,
                      "tier": "medium_2"
                    },
                    {
                      "factor": "borderline_qtc",
                      "points": 0,
                      "present": false,
                      "tier": "medium_2"
                    },
                    {
                      "factor": "arrhythmia",
                      "points": 0,
                      "present": false,
                      "tier": "medium_2"
                    },
                    {
                      "factor": "elevated_troponin",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "elevated_bnp",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "age_65_to_74",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "diabetes",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "hyperlipidemia",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "ckd",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "proteinuria",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "prior_left_chest_or_mediastinal_rt",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "current_or_significant_smoker",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    },
                    {
                      "factor": "obesity",
                      "points": 0,
                      "present": false,
                      "tier": "medium_1"
                    }
                  ],
                  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
                  "formula": "hfa_icos_vegf",
                  "formula_expression": "HFA-ICOS VEGF-inhibitor class (Lyon 2020): very_high if any very-high factor; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low. medium_points = Medium 2 + Medium 1 only. Very high: heart_failure_or_cardiomyopathy, arterial_vascular_disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). High: venous_thrombosis, lvef_percent<50, qtc_ms>=480, age_years>=75, hypertension, prior_anthracycline. Medium 2: lvef 50-54, male 450<=qtc<480, female 460<=qtc<480, arrhythmia (AF/flutter/VT/VF). Medium 1: elevated_troponin, elevated_bnp, age 65-74, diabetes, hyperlipidemia, ckd, proteinuria, prior_left_chest_or_mediastinal_rt, current_or_significant_smoker, obesity. Age exclusive (>=75 High; 65-74 Medium 1; <65 none). LVEF exclusive (<50 High; 50-54 Medium 2; >=55 none). QTc exclusive (>=480 High; else sex-specific Medium 2). cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
                  "high_factor": false,
                  "lvef_percent": 60,
                  "medium_points": 0,
                  "qtc_ms": 400,
                  "risk_level": "low",
                  "sex": "female",
                  "very_high_factor": false
                }
              ],
              "path": "/api/calc/hfa_icos_vegf"
            },
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          }
        },
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                            "description": "Integer age in years (18-100) as assigned by the caller. Lyon 2020 VEGF-inhibitor table: >=75 High; 65-74 Medium 1; <65 no age points. Bands are exclusive. magent does not read an identity document.",
                            "type": "integer"
                          },
                          "arrhythmia": {
                            "description": "Arrhythmia (atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 2). true or false.",
                            "type": "boolean"
                          },
                          "arterial_vascular_disease": {
                            "description": "Arterial vascular disease: IHD, PCI, CABG, stable angina, TIA, stroke, or PVD as one caller bool (Lyon 2020 VEGF-inhibitor table, very high). true or false. magent does not diagnose vascular disease.",
                            "type": "boolean"
                          },
                          "ckd": {
                            "description": "Chronic kidney disease (eGFR <60 mL/min/1.73 m2) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false. magent does not compute eGFR.",
                            "type": "boolean"
                          },
                          "current_or_significant_smoker": {
                            "description": "Current smoker or significant smoking history as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false.",
                            "type": "boolean"
                          },
                          "diabetes": {
                            "description": "Diabetes mellitus (glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false.",
                            "type": "boolean"
                          },
                          "elevated_bnp": {
                            "description": "Elevated baseline BNP or NT-proBNP above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false. magent does not assay BNP.",
                            "type": "boolean"
                          },
                          "elevated_troponin": {
                            "description": "Elevated baseline troponin above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false. magent does not assay troponin.",
                            "type": "boolean"
                          },
                          "heart_failure_or_cardiomyopathy": {
                            "description": "Heart failure or cardiomyopathy (Lyon 2020 VEGF-inhibitor table, very high). Caller-assigned. true or false.",
                            "type": "boolean"
                          },
                          "hyperlipidemia": {
                            "description": "Hyperlipidemia (non-HDL cholesterol >3.8 mmol/L or >145 mg/dL) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false. magent does not convert lipid units.",
                            "type": "boolean"
                          },
                          "hypertension": {
                            "description": "Hypertension (SBP >140 mmHg or DBP >90 mmHg, or on treatment) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, High). true or false. magent does not read a blood-pressure cuff.",
                            "type": "boolean"
                          },
                          "lvef_percent": {
                            "description": "Baseline left-ventricular ejection fraction, integer percent 10-80, as assigned by the caller. <50 High; 50-54 Medium 2; >=55 no LVEF points. magent does not read an echocardiogram.",
                            "type": "integer"
                          },
                          "obesity": {
                            "description": "Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false. magent does not compute BMI.",
                            "type": "boolean"
                          },
                          "prior_anthracycline": {
                            "description": "Prior anthracycline exposure as assigned by the caller (Lyon 2020 VEGF-inhibitor table, High). true or false.",
                            "type": "boolean"
                          },
                          "prior_left_chest_or_mediastinal_rt": {
                            "description": "Prior radiotherapy to the left chest or mediastinum as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false.",
                            "type": "boolean"
                          },
                          "proteinuria": {
                            "description": "Proteinuria as assigned by the caller (Lyon 2020 VEGF-inhibitor table, Medium 1). true or false.",
                            "type": "boolean"
                          },
                          "qtc_ms": {
                            "description": "Baseline QTc in milliseconds, integer 300-700, as assigned by the caller. >=480 High; men 450-479 Medium 2; women 460-479 Medium 2. magent does not measure QTc.",
                            "type": "integer"
                          },
                          "sex": {
                            "description": "male or female as assigned by the caller. Used only for the sex-specific borderline QTc Medium 2 band (men 450-479 ms; women 460-479 ms).",
                            "type": "string"
                          },
                          "venous_thrombosis": {
                            "description": "Venous thrombosis (DVT or PE) as assigned by the caller (Lyon 2020 VEGF-inhibitor table, High). true or false.",
                            "type": "boolean"
                          }
                        },
                        "required": [
                          "age_years",
                          "sex",
                          "lvef_percent",
                          "qtc_ms",
                          "heart_failure_or_cardiomyopathy",
                          "arterial_vascular_disease",
                          "venous_thrombosis",
                          "hypertension",
                          "prior_anthracycline",
                          "arrhythmia",
                          "elevated_troponin",
                          "elevated_bnp",
                          "diabetes",
                          "hyperlipidemia",
                          "ckd",
                          "proteinuria",
                          "prior_left_chest_or_mediastinal_rt",
                          "current_or_significant_smoker",
                          "obesity"
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                    "items"
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                  "type": "object"
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                "headers": {
                  "additionalProperties": {
                    "type": "string"
                  },
                  "type": "object"
                },
                "method": {
                  "const": "POST",
                  "type": "string"
                },
                "type": {
                  "const": "http",
                  "type": "string"
                }
              },
              "required": [
                "type",
                "method"
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              "type": "object"
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            "output": {
              "properties": {
                "example": {
                  "type": "object"
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                "type": {
                  "type": "string"
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              },
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                "type"
              ],
              "type": "object"
            }
          },
          "required": [
            "input"
          ],
          "type": "object"
        }
      }
    }
  },
  "liveness": {
    "reliability": null
  },
  "verified": false,
  "featured": false,
  "provider": {
    "host": "api.magentlab.com",
    "manifest_name": "api.magentlab.com",
    "source": "cdp-mirror",
    "source_manifest_url": "https://api.cdp.coinbase.com/platform/v2/x402/discovery/resources",
    "submitted_at": "2026-10-14T01:15:01.050Z"
  },
  "exampleResponse": {
    "example": {},
    "type": "string"
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}