FDA drug-approval catalyst change stream for US-listed biotechs: every state change of eve
FDA drug-approval catalyst change stream for US-listed biotechs: every state change of every tracked catalyst — each PDUFA date as set, extended and resolved — with the real outcome (approval or CRL), the SEC filing quote and its EDGAR source, as a since-cursor delta feed. Use when you mirror the calendar and need date changes and outcomes as they land, not a snapshot. Accuracy AND coverage are free at GET /v1/accuracy. Flat price per request.
50000 (raw units)
price
12
calls / 30d
1
unique payers
2026-09-06
updated
Provider
api.biotechcatalystsentinel.com · discovered, not yet claimed by its owner
Payment (x402 accepts[])
[
{
"scheme": "exact",
"network": "eip155:8453",
"payTo": "0xcD8975137D48ED9bfD1C299a62c01420B860070d",
"asset": "0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913",
"amount": "50000",
"maxTimeoutSeconds": 300
},
{
"scheme": "exact",
"network": "solana:5eykt4UsFv8P8NJdTREpY1vzqKqZKvdp",
"payTo": "3gM4YDDPAi7w1di7rHAAaHc5T1tR7NRXzLWzPPN4ZRaM",
"asset": "EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v",
"amount": "50000",
"maxTimeoutSeconds": 300
}
]Output schema
{
"bazaar": {
"info": {
"input": {
"method": "GET",
"queryParams": {
"limit": 100,
"since": 0
},
"type": "http"
},
"output": {
"example": {
"data": [
{
"accession": "0009999001-25-000090",
"application_number": "BLA999901",
"applied": true,
"authority": "llm_high",
"catalyst_id": 990001,
"company": "Sample Therapeutics, Inc.",
"confidence": "high",
"date_changed": true,
"date_confidence": "confirmed",
"days_to_date": null,
"delta_days": null,
"detected_at": "2025-11-03T13:41:09.000000+00:00",
"drug_name": "SAMPLIMAB",
"event_id": 990101,
"event_type": "new_date_assigned",
"filed_at": "2025-11-03",
"indication": "sample indication (moderate-to-severe examplitis)",
"merged_into": null,
"new_date": "2026-04-18",
"new_date_upcoming": false,
"outcome": null,
"prior_date": null,
"source_quote": "The FDA has assigned a PDUFA target action date of April 18, 2026 for SAMPLIMAB. [FICTIONAL SAMPLE — not a real filing sentence]",
"source_url": "https://www.sec.gov/Archives/edgar/data/9999001/000999900125000090/0009999001-25-000090-index.htm",
"ticker": "XSMPL",
"tickers": [
"XSMPL",
"XPRTN"
]
}
],
"meta": {
"has_more": false,
"limit": 100,
"next_since": 990106,
"total": 1
}
},
"type": "json"
}
},
"schema": {
"$schema": "https://json-schema.org/draft/2020-12/schema",
"properties": {
"input": {
"additionalProperties": false,
"properties": {
"method": {
"enum": [
"GET",
"HEAD",
"DELETE"
],
"type": "string"
},
"queryParams": {
"properties": {
"limit": {
"default": 100,
"description": "Maximum number of events to return (1-500; default 100).",
"maximum": 500,
"minimum": 1,
"type": "integer"
},
"since": {
"description": "Cursor: return only events with an event_id greater than this (0 = from the start). Pass the last event_id you saw to page forward.",
"minimum": 0,
"type": "integer"
},
"ticker": {
"description": "Optional server-side filter: only events whose record is filed by this ticker's issuer or exposes it as a co-filer in tickers[] (case-insensitive). Composes with since — limit counts matched events, so a filtered backlog drains without gaps. Unknown ticker returns an empty 200. Does not change the price.",
"maxLength": 12,
"minLength": 1,
"pattern": "^\\S+$",
"type": "string"
}
},
"required": [],
"type": "object"
},
"type": {
"const": "http",
"type": "string"
}
},
"required": [
"type",
"method"
],
"type": "object"
},
"output": {
"properties": {
"example": {
"properties": {
"data": {
"description": "One row per state change, oldest-first while draining a `since` cursor. `tickers` lists every co-filer exposed to the decision.",
"items": {
"properties": {
"accession": {
"type": [
"string",
"null"
]
},
"application_number": {
"type": [
"string",
"null"
]
},
"applied": {
"type": "boolean"
},
"authority": {
"enum": [
"human_lock",
"llm_high",
"regex",
"llm_medium",
"llm_low",
null
],
"type": [
"string",
"null"
]
},
"catalyst_id": {
"type": "integer"
},
"company": {
"type": [
"string",
"null"
]
},
"confidence": {
"enum": [
"high",
"medium",
"low",
null
],
"type": [
"string",
"null"
]
},
"date_changed": {
"type": "boolean"
},
"date_confidence": {
"enum": [
"confirmed",
"reported",
"estimated",
null
],
"type": [
"string",
"null"
]
},
"days_to_date": {
"type": [
"integer",
"null"
]
},
"delta_days": {
"type": [
"integer",
"null"
]
},
"detected_at": {
"type": [
"string",
"null"
]
},
"drug_name": {
"type": [
"string",
"null"
]
},
"event_id": {
"type": "integer"
},
"event_type": {
"enum": [
"new_date_assigned",
"date_extension",
"decision_outcome",
"retracted",
"restored",
"corrected"
],
"type": "string"
},
"filed_at": {
"type": [
"string",
"null"
]
},
"indication": {
"type": [
"string",
"null"
]
},
"merged_into": {
"type": [
"integer",
"null"
]
},
"new_date": {
"type": [
"string",
"null"
]
},
"new_date_upcoming": {
"type": "boolean"
},
"outcome": {
"enum": [
"approved",
"tentative",
"crl",
"none_found",
null
],
"type": [
"string",
"null"
]
},
"prior_date": {
"type": [
"string",
"null"
]
},
"source_quote": {
"type": [
"string",
"null"
]
},
"source_url": {
"type": [
"string",
"null"
]
},
"ticker": {
"type": [
"string",
"null"
]
},
"tickers": {
"items": {
"type": "string"
},
"type": "array"
}
},
"required": [
"event_id",
"catalyst_id",
"event_type"
],
"type": "object"
},
"type": "array"
},
"meta": {
"description": "Result metadata, e.g. total count.",
"type": "object"
}
},
"type": "object"
},
"type": {
"type": "string"
}
},
"required": [
"type"
],
"type": "object"
}
},
"required": [
"input"
],
"type": "object"
}
}
}Use it
curl
curl "https://api.biotechcatalystsentinel.com/v1/events" # -> 402 Payment Required, accepts[] lists how to pay # retry with a PAYMENT-SIGNATURE (or PAYMENT header) once paid
JavaScript
const res = await fetch("https://api.biotechcatalystsentinel.com/v1/events");
if (res.status === 402) {
const { accepts } = await res.json();
// pay one of accepts[] via an x402 client, then retry with the payment header
}Python
import httpx
res = httpx.get("https://api.biotechcatalystsentinel.com/v1/events")
if res.status_code == 402:
accepts = res.json()["accepts"]
# pay one of accepts[] via an x402 client, then retry with the payment headerMachine-readable
Everything on this page is also available as clean JSON at /resources/3592.json, and this resource appears in /discovery/resources and /discovery/search.